Comprehensive Evaluation of Powdered Chinese Herbal Medicines-An Exemplification of Isatidis Radix  

作　　者：Xue Han Ming-quan Wu Zhi-rui Yang Ding-kun Zhang Yi Mao Jin Han Yin-qiu Huang Yong-feng Zhou Yan-ling Zhao Jia-bo Wang Xiao-he Xiao 

机构地区：[1]College of Pharmacy, Chengdu University of Traditional Chinese Medicine [2]China Military Institute of Chinese Medicine, 302 Military Hospital [3]Department of Pharmacy, 302 Military Hospital [4]Department of Integrative Medical Center, 302 Military Hospital

出　　处：《Chinese Herbal Medicines》2016年第3期286-292,共7页中草药（英文版）

基　　金：National Natural Science Foundation of China(81473316)

摘　　要：Objective Currently, powdered Chinese herbal medicines （CHMs） were mainly evaluated through physical property, chemical dissolution, and bioactivity independently. It could not reflect the quality comprehensively. This paper was to explore and establish a comprehensive evaluation method for powdered CHMs. Methods Isatidis Radixwas chosen as an exemple. Firstly, powdered Isatidis Radixin different particle size was prepared. Then, their physical properties were characterized. The dissolution of index component epigoitrin was determined, and their antiviral activities were evaluated by neuraminidase-based bioassay. Results As the particle size decreased, powder distribution tended to be uniform, and the dissolution of epigoitrin increased, antiviral activity enhanced. According to cluster analysis of above results, the sequence of evaluation consequence was ultrafine powder S2 （D90：32.80± 0.29） 〉 ultrafine powder S1 （D90：52.08 ± 0.53） 〉 fine powder SO （D90：118.16± 0.76） （from the superior to the inferior）. Conclusion Overall, the comprehensive evaluation for powdered CHMs based on the physical characterization, chemical dissolution, and bioassay could not only be used to evaluate powdered herbs, but also guide the screening and optimization of the particle size of powder.Objective Currently, powdered Chinese herbal medicines （CHMs） were mainly evaluated through physical property, chemical dissolution, and bioactivity independently. It could not reflect the quality comprehensively. This paper was to explore and establish a comprehensive evaluation method for powdered CHMs. Methods Isatidis Radixwas chosen as an exemple. Firstly, powdered Isatidis Radixin different particle size was prepared. Then, their physical properties were characterized. The dissolution of index component epigoitrin was determined, and their antiviral activities were evaluated by neuraminidase-based bioassay. Results As the particle size decreased, powder distribution tended to be uniform, and the dissolution of epigoitrin increased, antiviral activity enhanced. According to cluster analysis of above results, the sequence of evaluation consequence was ultrafine powder S2 （D90：32.80± 0.29） 〉 ultrafine powder S1 （D90：52.08 ± 0.53） 〉 fine powder SO （D90：118.16± 0.76） （from the superior to the inferior）. Conclusion Overall, the comprehensive evaluation for powdered CHMs based on the physical characterization, chemical dissolution, and bioassay could not only be used to evaluate powdered herbs, but also guide the screening and optimization of the particle size of powder.

关 键 词：chemical dissolution comprehensive evaluation Isatidis Radi neuraminidase-basedbioassay physical characterization powdered Chinese herbal medicine 

分 类 号：R286.0[医药卫生—中药学]