Twist对EMT调控在循环肿瘤细胞监测与抗癌药物评价中的临床意义  

Twist regulation of EMT and its clinical significance in monitoring circulating tumor cells and evaluating effects of anticancer drugs

作　　者：李文卿[1] 丁怡[1] 姜雨[1] 路中[1] 王丽华[1] Wenqing LI Yi DING Yu JIANG Zhong LU Lihua WANG(Laboratory of Molecular Oncology, Affiliated Hospital, Weifang Medical College, Weifang 261053, China)

机构地区：[1]潍坊医学院分子肿瘤学研究室,潍坊医学院附属医院,山东省潍坊市261053

出　　处：《中国肿瘤临床》2016年第17期770-774,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81472489);山东省科技发展计划项目(编号:2014GSF118040)资助~~

摘　　要：肿瘤细胞的上皮间质可塑性变化包括上皮-间质化(epithelial-mesenchymal transition,EMT)和间质-上皮转化(mesenchymal-epithelial transition,MET)的可逆过程,在循环肿瘤细胞(circulating tumor cells,CTCs)形成、转归及肿瘤转移过程中起到重要作用。Twist在人横纹肌肉瘤、乳腺癌、胃癌等多种肿瘤中过表达,肿瘤细胞中Twist与多种信号通路连接,形成复杂的网状环路参与调控CTCs中EMT/MET的发生并促进肿瘤细胞向远处转移。因此,通过监测CTCs中Twist本身以及所调控的上皮-间质表型分子标志物的变化,不仅可以增加肿瘤标志物CTCs的检出率,提供肿瘤临床分期及预后评估的直接证据;而且,对于评估多种抗肿瘤药物的疗效及耐药机制均具有重要的临床意义。Tumor cell plasticity, including epithelial to mesenchymal transition （EMT） and its reverse program, mesenchymal to epithelial transition （MET）, regulates circulating tumor cells and carcinoma metastasis. Twist is overexpressed in rhabdomyosarcoma, breast cancer, gastric cancer, and other tumors. Twist, as a transcriptional factor, cross-talks with multiple signaling pathways, forming a complex network to participate in the regulation of EMT/MET in circulating tumor cells, which in turn promotes metastasis of tumor cells. Therefore, monitoring the level of Twist and epithelial - mesenchymal phenotypic molecules is important as it may be beneficial for increasing the detection ratio of circulating tumor cells as tumor biomarkers and for evaluating the effects of anticancer drugs.

关 键 词：TWIST 上皮-间质转化 循环肿瘤细胞 肿瘤标志物 抗肿瘤药物 

分 类 号：R979.1[医药卫生—药品]