NB-UVB对特应性皮炎患者外周血IL-23/IL-17轴表达的影响  

Effects of Narrow-band Ultraviolet B on Expression of IL-23/IL-17 Axis in Peripheral Blood of Patients with Atopic Dermatitis

作　　者：邱会芬[1] 王雯[2] 王忠永[1] 胡海友[1] 孙其乐 高昱[1] QIU Hui-fen WANG Wen WANG Zhong-yong HU I-Iai-you SUN Qi-le GAO Yu(Department of Dermatology, the Affiliated Hospital of Binzhou Medical College, Binzhou 256603, China Remote Medical Center, People＇s Liberation Army General Hospital, Beijing 100853, China)

机构地区：[1]滨州医学院附属医院皮肤科,山东滨州256603 [2]解放军总医院远程医学中心,北京100853

出　　处：《中国皮肤性病学杂志》2016年第10期1010-1013,共4页The Chinese Journal of Dermatovenereology

基　　金：山东省科技发展计划(2011YD18008)

摘　　要：目的观察窄谱中波紫外线(NB-UVB)治疗特应性皮炎(AD)的临床疗效及其对外周血白介素-17A(IL-17A)、白介素-17F(IL-17F)、白介素-23(IL-23)、白介素-22(IL-22)等水平的影响,探讨NB-UVB治疗AD的作用机制。方法选取60例AD患者,予NB-UVB照射治疗8周,采用双抗体夹心ELISA法检测光疗前后患者血清中IL-17A,IL-17F,IL-23,IL-22和白介素-21(IL-21)的含量。采用欧洲AD评分标准(SCORAD)判断疾病严重程度,采用视觉模拟标尺法(VAS)评价瘙痒程度。另选30例健康体检者作为正常对照组。结果 AD患者血清中IL-17A,IL-17F,IL-23,IL-22和IL-21水平均显著高于正常对照组,且差异均有统计学意义(P均<0.01);NB-UVB治疗后患者血清IL-17A,IL-17F,IL-23,IL-22和IL-21水平明显降低,与治疗前相比,差异均有统计学意义(P均<0.01)。经NB-UVB治疗8周后,SCORAD及VAS评分均较治疗前明显下降(P均<0.01)。总有效率为88.33%。结论 NB-UVB照射可明显下调AD患者外周血IL-17A,IL-17F,IL-23,IL-22及IL-21水平,这可能是NB-UVB治疗AD的机制之一;NB-UVB治疗AD安全有效。Objective To observe the clinical efficacy of narrow-band uhraviolet B （NB-UVB）and its influence on the expression of interleukin-17A （ IL-17A）, interleukin-17F （ IL-17F）, interleukin-23 （ IL-23 ） and interleukin-22 （IL-22） in peripheral blood of patients with atopic dermatitis （AD）, in order to investigate the underlying mechanisms of NB-UVB. Methods Sixty patients were recruited and treated with NB-UVB therapy for 8 weeks. An enzyme-linked immunosorbent assay（ELISA） was used to measure the serum levels of IL-17A, IL- 17F,IL-23 ,IL-22 and IL-21 before and after treatment. Assessing to severity scoring of AD by scoring atopic dermatitis （SCORAD）and the degree of the itch by using visual analogue scale（VAS）. Thirty healthy persons were used as normal controls. Results Before treatment, the serum levels of IL-17A, IL-17F, IL-23,IL-22 and IL-21 were significantly higher in patient with AD than those in the normal controls （P 〈 0. 01 ）. After the NB-UVB treatment,the levels of serum IL-17A,IL-17F, IL-23, IL-22 and IL-21 were decreased significantly （P 〈 0. 01 ）. After 8 weeks of treatment with NB-UVB, both SCORAD index and VAS index were decreased significantly（P 〈0. 01 ）. The total effective rate was 88. 33% . Conclusion NB-UVB is able to down-regulate the levels of IL-17A, IL-17F, IL-23, IL-22 and IL-21 expression significantly, which may be one of the mechanisms of NB-UVB treatment for AD. The clinical data demonstrate that NB-UVB is a safe and effective therapy for AD.

关 键 词：特应性皮炎 窄谱中波紫外线 白介素-17 白介素-23 白介素-22 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]