艾塞那肽联合川芎嗪对肾功能正常2型糖尿病患者肾内血流动力学的影响  

Effect of Exenatide combined with Ligustrazine on intrarenal hemodynamics in T2DM patients in early period

作　　者：王娇[1] 关清华[2] 周月宏[1] 

机构地区：[1]沈阳医学院附属中心医院,辽宁沈阳110024 [2]辽宁省沈阳市第四人民医院,辽宁沈阳110031

出　　处：《现代中西医结合杂志》2016年第28期3091-3094,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：沈阳市科技计划基金项目(F13-220-9-10)

摘　　要：目的观察艾塞那肽联合川芎嗪对肾功能正常2型糖尿病(T2DM)患者肾内血流动力学的影响。方法将肾功能正常的T2DM患者随机分为观察组和对照组。2组均给予艾塞那肽+二甲双胍+羟苯磺酸钙胶囊治疗,观察组在此基础上给予磷酸川芎嗪片口服,2组均连续治疗30 d。观察2组治疗前后空腹血糖(FBG)、餐后2 h血糖(2h PG)、体质量指数(BMI)与肾功能情况,并用彩超测定左右肾实质中部叶间动脉的阻力指数(RI),记录治疗过程中不良反应发生情况。结果治疗后2组FBG、2h PG均明显低于治疗前(P均<0.05),BMI均无明显变化(P均>0.05),治疗后2组FBG、2h PG、BMI比较差异均无统计学意义(P均>0.05);治疗后2组左右肾实质中部叶间动脉RI、肾小球滤过率(GFR)、血清肌酐(Cr)、血清尿素氮(BUN)、尿蛋白排泄率(UAER)、尿微量白蛋白肌酐比值(UACR)均明显降低(P均<0.05),且观察组各指标改善情况均明显优于对照组(P均<0.05)。治疗过程中2组均未发生严重不良反应,仅出现轻度恶心感与皮肤瘙痒感,且2组发生率比较差异无统计学意义(P>0.05)。结论在肾功能正常的T2DM患者治疗中加用川芎嗪能很好改善双肾血流动力学及肾功能,方法安全可靠。Objective It is to observe the effect of Exenatide combined with Ligustrazine on intrarenal hemodynamic in T2 DM patients with normal renal function in early period. Methods The T2 DM patients with normal renal function were randomly divided into observation group and control group. Both groups were treated with Exenatide ＋ Metformin ＋ Dobes,and the observation group was given Ligustrazine additionally,they were all treated for 30 days. The changes of fasting plasma glucose（ FBG）,2- hour postprandial blood glucose（ 2h PBG）,body mass index（ BMI）,and renal function were observed,intrarenal hemodynamic（ bilateral kidney RI） in bilateral interlobular renal arteries were evaluated using Doppler Sonographic before and after treatment,the adverse events（ AEs） were recorded during treatment. Results After treatment,FBG,2h PBG were both lower than before treatment in both groups（ P 0. 05）,no obvious change of BMI was found. FBG,2h PBG had no statistical differences between the two groups（ P 0. 05）. After treatment the intrarenal hemodynamic（ bilateral kidney RI） in bilateral interlobular renal arteries,glomerular filtration rate（ GFR）,creatinine（ Cr）,blood urea nitrogen（ BUN）,and albumin excrete rate（ AER） were lower than that before treatment in both groups（ P 0. 05）,and the decreases were more significant in the observation group than that in control group（ P 0. 05）. No serious AEs was found during treatment,only someone had gastrointestinal events,skin- related AEs,the incidences of AEs had no statistical difference between the two groups. Conclusion Adding Ligustrazine in the treatment for T2 DM patients with normal renal function can improve the intrarenal hemodynamic and can increase the renal function with a good safety and reliability.

关 键 词：2型糖尿病 肾内血流动力学 阻力指数 艾塞那肽 川芎嗪 

分 类 号：R587.1[医药卫生—内分泌]