疏血通注射液联合利伐沙班预防髋部手术后下肢深静脉血栓形成疗效观察  

Observation of curative effect of Shuxuetong injection combined with rivaroxaban in the prevention for lower limb deep vein thrombosis formation after hip surgery

作　　者：解俊杰 杨雷刚 任军龙 

机构地区：[1]陕西省咸阳市中心医院,陕西咸阳712000

出　　处：《现代中西医结合杂志》2016年第28期3111-3114,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察疏血通注射液联合利伐沙班预防髋部手术后下肢深静脉血栓形成(DVT)的临床效果。方法将314例髋部手术患者随机分为利伐沙班组和联合组各157例,利伐沙班组术后6 h给予利伐沙班治疗,联合组在利伐沙班组基础上给予疏血通注射液治疗,2组均以7 d为1个疗程,均连续治疗2个疗程。观察2组术前及术后24 h、7 d、14 d内皮素(ET)、血栓素B_2(TXB_2)、6-酮前列腺素F1α(6-Keto-PGF1α)水平及血小板计数(Plt)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT),统计2组术后指标和DVT发生率。结果术后24 h、7 d,联合组ET、TXB_2水平均明显低于利伐沙班组(P均<0.05),6-KetoPGF1α水平均高于利伐沙班组(P均<0.05);术后14 d,2组ET、TXB_2、6-Keto-PGF1α水平比较差异均无统计学意义(P均>0.05)。2组术前及术后24 h、7 d、14 d Plt、APTT和PT比较差异均无统计学意义(P均>0.05)。2组术后引流量、总输血量、显性红细胞丢失量和隐性红细胞丢失量比较差异均无统计学意义(P均>0.05)。2组均无肺栓塞发生,联合组DVT发生率明显低于利伐沙班组(P<0.05)。结论疏血通注射液联合利伐沙班可降低髋部手术后DVT发生率,具有临床推广价值。Objective It is to observation the clinical effect of Shuxuetong injection combined with rivaroxaban in the prevention for lower limb deep vein thrombosis formation（ DVT） after hip surgery. Methods 314 cases of patients accepted hip surgery were randomly divided into rivaroxaban group and combination group,157 cases in each group. Rivaroxaban group was given rivaroxaban in 6h after operation,combination group was given Shuxuetong injection on the basis of treatment in rivaroxaban group. 7 days was a course of treatment,and both groups were treated for 2 courses. The levels of endothelial prime（ ET）,thromboxane B_2（ TXB_2）,6 keto prostaglandin F1（ 6- Keto- PGF1α and platelet count（ Plt）,activated partial thromboplastin time（ APTT）,prothrombin time（ PT） were observed in both groups before operation and in 24 h,7 d,14 d after operatioin. Postoperative indicators and DVT incidence in both groups were observed too. Results In 24 h and 7 days after operation,the levels of ET and TXB_2 were significantly lower while that of 6- Keto- PGF1α was higher in combination group than that in rivaroxaban group（ P 0. 05）. In 14 days after operation,there was no significant difference in the levels of indexes above between the two groups（ P 0. 05）. There was no significant difference in Plt,APTT and PT between the two groups before and after operation（ P 0. 05）. There was no significant difference in drainage volume,total volume of blood transfusion,visible red blood cell loss and recessive red cell loss between the two groups after operation（ P 0. 05）. No pulmonary embolism occurred,the incidence rate of DVT in combination group was significantly lower than that in the rivaroxaban group（ P 0. 05）. Conclusion Shuxuetong injection combined with rivaroxaban can reduce the incidence of DVT after hip surgery,which is worthy of clinical application and promotion.

关 键 词：髋部手术 深静脉血栓形成 疏血通注射液 利伐沙班 内皮素 血栓素B2 6-酮前列腺素F1Α 

分 类 号：R543.6[医药卫生—心血管疾病]