孕期RH血型不合孕妇应用抗D免疫球蛋白治疗20例临床研究  

Clinical research on treating RH incompatibility for 20 pregnant women by using anti D immunoglobulin

作　　者：刘巧英[1] 高丽萍[1] 翟锦娣[1] 王春红[1] 

机构地区：[1]广东省博罗县人民医院产科,516100

出　　处：《齐齐哈尔医学院学报》2016年第19期2387-2388,共2页Journal of Qiqihar Medical University

摘　　要：目的观察20例RH血型不合的孕妇孕期应用抗D免疫球蛋白治疗的疗效以及不良反应。方法选择2014年2月至2015年10月我院就诊的RH血型不合的孕妇20例,应用抗D免疫球蛋白治疗作为观察组,另18例RH血型不合的孕妇拒绝采用预防措施作为对照组,分别对比两组孕妇及胎儿的死亡率、新生儿溶血的发生率,并对结果进行分析。结果观察组孕妇无死亡病例发生、有1例胎儿出现不明原因死产计入统计;对照组孕妇死亡3例、胎儿死亡5例;(P<0.05);观察组胎儿或新生儿中发生贫血2例、水肿3例、核黄疸1例(死亡1例);对照组胎儿或新生儿中发生贫血5例(死亡1例)、水肿6例(死亡2例)、核黄疸3例(死亡2例),两组比较具有显著差异(P<0.05)。结论通过应用抗D免疫球蛋白治疗针对RH血型不合孕妇来说,具有预防死产及孕妇死亡的价值;并且可以有力的减轻及减少新生儿溶血病的发生,可以作为预防措施进行推广。Objective To observe-the curative effect of anti D protein in treating RH blood type incompatibility for 20 cases of pregnant women, and observe the adverse reactions. Methods During February 2014 and November 2014, 20 cases of pregnant women suffering from RH blood incompatibility and received application of D protein for therapy in our hospital group were chose as observation group, another 18 cases of pregnant women with RH blood type incompatibility refused to adopt preventive measures were included as control group. The mortality of pregnant women and fetal of the two groups were compared, as well as the incidence of neonatal hemolysis, and analyzed the results. Results In the observation group, none pregnant women dead, but one fetus was unexplained stillbirths which included in the statistics. In the control group, 3 cases of pregnant women and 5 cases of fetal dead, the mortality of pregnant women and fetal was higher than those than the observation group （P 〈 0. 05）. In observation group fetal or neonatal anemia occurred in 2 cases, edema occurred in 3 cases, 1 case of nuclear jaundice （died）. Fetal or neonatal anemia occurred in 5 cases in control group （ 1 case was died）, 6 cases of edema （2 cases died）, 3 patients suffered from nuclear jaundice （2 cases died）, there were significant differences between the two groups （ P 〈 0. 05 ）. Conclusions The application of D protein therapy for RH blood type incompatibility pregnant women, have the value of prevent stillbirth and death of pregnant women. It can reduce the occurrence of neonatal hemolytic disease powerfully, also can be used as a preventive measure to promote it.

关 键 词：孕妇 RH血型不合 抗D免疫球蛋白 新生儿溶血 

分 类 号：R722.18[医药卫生—儿科]