当归补血汤加味治疗白细胞减少症疗效的Meta分析  

Modified Danggui Buxue Decoction for Leukopenia: A Meta- analysis

作　　者：窦昊颖[1] 张盼盼[1] 高晓宁[1] 梁芳芳[1] 陈珊珊[1] 王云云[1] 王晓玲 汪涛 

机构地区：[1]天津中医药大学护理学院,天津300193 [2]天津中药医药大学中西医结合学院,天津300193

出　　处：《辽宁中医杂志》2016年第9期1807-1811,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81273892);国家自然科学基金青年项目(81503401)

摘　　要：目的:系统评价当归补血汤加味治疗白细胞减少症的疗效。方法:计算机检索中国知网、万方数据库、维普数据库及中国生物医学文献数据库,以及The Cochrane Library、Embase、Medline与Pubmed等国外数据库,查找当归补血汤加味方治疗白细胞减少症的随机对照试验,检索时间限为各数据库建库至2015年9月。根据纳入和排除标准,两位研究人员分别独立进行文献检索、筛选、质量评价和数据提取,通过Rev Man 5.3软件进行Meta分析。结果:共纳入4个随机对照试验研究,总样本量为386例。Meta分析结果显示,当归补血汤加味治疗白细胞减少症总有效率高[RR=1.34,95%CI(1.10,1.62),P=0.003],患者白细胞计数高于对照组[RR=0.83,95%CI(0.60,1.07),P<0.00001],且差异均有统计学意义。结论:当归补血汤加味治疗白细胞减少症的疗效优于常规西药,但本研究纳入的随机对照试验较少,仍需更多大样本、高质量的多中心随机双盲对照试验对当归补血汤加味治疗白细胞减少症的疗效加以验证。Objective： To systematically evaluate the efficacy of Modified Danggui Buxue Decoction for the treatment, of leuko- penia. Methods ： All researches on the RCTs of leukopenia treated by Modified Danggui Buxue Decoction were retrieved and eol.- lected from CNKI, WANFANG, Database of VIP, CBM, PubMed, Embase, Medline and the Cochrane Library （from the date of their establishments to September 2015 ）. Two researchers performed literature retrieval, selection, methodological quality evalua-tion and data extracting independently. The Meta - analysis was performed by RevMan 5.3 software. Results ：Totally d RCTs invol- ving 386 patients were included. The results of Meta - analyses showed that the efficacy of Modified Danggui Buxue Decoction for leukopenia was better than western medicine for leukopenia and the differences were significant in terms of total effective rate [ RR = 1.34,95 % CI （ I. I 0,1.62 ）, P = 0.003 ] and leukocyte count [ RR = 0. 83,95 % CI （0. 60,1.07 ）, P 〈 0. 00001 ~. Conclu- sion ： The effect of Modified Danggui Buxue Decoction was better than western medicine. However, the number of randomized con- trol trials included were small. Therefore, rigorous designs, randomized, double - blind, placeo - controlled trials of Modified Dang- gui Buxue Decoction for leukopenia were still needed to further assess the effect.

关 键 词：当归补血汤加味 白细胞减少症 META分析 

分 类 号：R259.571[医药卫生—中西医结合]