MPO对急性冠脉综合征早期筛查的临床意义  

The Clinical Significance of Myeloperoxidase in Early Screening in Patients with Acute Coronary Syndrome

作　　者：马学华[1] 宋志伟[1] 叶向梅[2] 林春艳[1] 冯磊光[1] 

机构地区：[1]哈尔滨医科大学附属第一医院检验科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第一医院中心实验室,黑龙江哈尔滨150001

出　　处：《标记免疫分析与临床》2016年第9期973-976,共4页Labeled Immunoassays and Clinical Medicine

基　　金：国家高技术研究发展计划(863计划)(2011AA02A111)

摘　　要：目的 探讨髓过氧化物酶（MPO）对急性冠脉综合征（ACS）患者的早期筛查意义.方法 参照ACC/AHA指南收集两组病例,其中ACS组164例,稳定性心绞痛（SAP）组105例.同时选取76例冠脉造影正常者作为对照组.ACS组又分为两组,其中心肌梗死（AMI）组71例,不稳定性心绞痛（UA）93例.检测所有入选者一般生化学指标及心肌肌钙蛋白I（cTnI）、超敏C反应蛋白（hs-CRP）、髓过氧化物酶（MPO）水平.结果 ACS组血浆总胆固醇水平高于对照组,cTnI、hsCRP、MPO高于SAP组及对照组（P＜0.05）,SAP组hs-CRP高于对照组（P＜0.05）.AMI组胸痛发生后6～72小时cTnI水平高于SAP组和UA组（P ＜0.05）;UA组12 ～72小时cTnI水平高于SAP组（P＜0.05）.AMI组胸痛发生后12～72小时hs-CRP水平高于SAP组和UA组（P＜0.05）;UA组胸痛发生后12～ 72小时hs-CRP水平高于SAP组（P＜0.05）.AMI组胸痛发生后2～48小时MPO水平高于SAP组,2～24小时高于UA组（P ＜0.05）;UA组2～24小时MPO水平高于SAP组（P＜0.05）.结论 MPO可预测ACS患者的预后,能有效的筛查其他心肌损伤标志物不高的ACS患者.Objective To investigate the myeloperoxidase （MPO） in patients with acute coronary syndrome （ACS） patients with early screening significance. Methods Based on ACC/AHA guidelines, two groups were assigned, 164 patients in ACS group and 105 patients with stable angina pectoris （SAP）. At the same time, 76 cases with normal coronary angiography were selected as the control group. The ACS group was further divided into acute myocardial infarction （AMI） group with 71 cases and unstable angina （UA） with 93 cases. The routine chemical index, cardiac troponin I （cTnI）, high sensitivity C reactive protein （hs- CRP）, myeloperoxidase （MPO） levels were detected in all subjects. Results Total cholesterol levels in ACS group were higher than that in control group, hs-CRP, MPO and cTnI were significantly higher than those in SAP group and control group （P 〈 0.05 ）. hs-CRP in SAP group was significantly higher than that in control group （P 〈 0.05 ）. The level of cTnI in AMI group was higher than that in SAP group and UA group during 6-72 hours after chest pain （ P 〈 0.05 ）. The cTnI level of SAP group was higher than that in UA group during 12-72 hours（ P 〈 0.05 ）. The level of hs-CRP in group AMI was higher than that in SAP group and UA group during 12-72 hours after chest pain （P 〈 0.05 ）. The level of hs-CRP in group UA was higher than that in SAP group during 12-72 hours after chest pain（ P 〈 0.05 ）. The level of MPO in group AMI was higher than that in group SAP at 2-48 hours after chest pain, and higher than that in group UA at 2-24 hours（P 〈0.05）. The MPO level of SAP group was higher than that in UA group during 2-24 hours （ P 〈 0.05 ）. Conclusion MPO can predict the prognosis of patients with ACS, and can effectively screen the ASC patients with other cardiac markers of myocardial damage.

关 键 词：髓过氧化酶 急性冠脉综合症 急性心肌梗死 稳定性心绞痛 心肌肌钙蛋白I 

分 类 号：R541.4[医药卫生—心血管疾病]