树枝状大分子在荧光生物成像中的研究进展  

An Overview of Dendrimers Used in Fluorescent Bioimaging

作　　者：左云飞[1,2] 王星[1,2] 杨飞[1,2] 沈红[1,2] 吴德成[1,2] 

机构地区：[1]中国科学院化学研究所,高分子物理与化学国家重点实验室,北京100190 [2]中国科学院大学,北京100049

出　　处：《高分子通报》2016年第9期189-195,共7页Polymer Bulletin

基　　金：国家自然科学基金(21474115)

摘　　要：树枝状大分子是一种具有精确三维结构的纳米材料。目前,对于树枝状大分子的研究,逐渐从合成和表征各式各样的树枝状大分子转向到对其特殊功能和应用的研究。传统的荧光成像探针大多数为小分子化合物,其发展受到特异性低、稳定性差、停留时间短、可修饰基团少和毒性大等缺点的限制。树枝状大分子具备独特的分子结构如大量可设计性的末端官能团和广阔的分子内空腔以及选择多样化的优势,使其在荧光生物成像领域中有良好的应用前景。本文重点介绍了基于树枝状大分子的有机荧光探针和量子点探针在生物成像方面最新的研究进展。Dendrimers are a kind of nanomaterials with precise three dimensional structures. Recently, an emerging attention is received from synthesis and characterization of dendrimers towards their functions and applications. Currently, most of traditional fluorescence imaging probes developed are small molecules, but the weak specificity, poor stability, short duration time, and high toxicity greatly limit their applications. Dendrimers with many designable terminal functional groups and large intramolecular cavities are promising for applications in fluorescent biological imaging due to theirs diversity and unique molecular structures. Herein, we mainly introduce the recent progress of dendritic organic fluorescent probes and quantum dots probes for bioimaging.

关 键 词：树枝状大分子 荧光探针 生物成像 

分 类 号：O657.3[理学—分析化学]