中药序贯疗法对支气管哮喘儿童哮喘控制测试、嗜酸性粒细胞阳离子蛋白及免疫球蛋白E的影响  

Effect of TCM sequential therapy on asthma control test to children,eosinophile cationic protein and immunoglobulin E in children bronchial asthma

作　　者：项李娥[1] 尚莉丽[1] XIANG Li＇ e SHANG Lili(Pediatric Department of the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230038, Chin)

机构地区：[1]安徽中医药大学第一附属医院儿科,安徽合肥230038

出　　处：《中医儿科杂志》2016年第5期26-30,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：安徽省自然科学基金(11040606M186)

摘　　要：目的观察中药序贯疗法对支气管哮喘儿童哮喘控制测试(C-ACT)评分、血清嗜酸性粒细胞阳离子蛋白(ECP)、免疫球蛋白E(IgE)水平的影响,并初步探讨中药序贯疗法治疗儿童哮喘的作用机制。方法将符合本研究纳入标准的支气管哮喘患儿60例随机分为治疗组和对照组,各30例。对照组急性发作期吸入氟替卡松,治疗组急性期予温肺止咳平喘方、缓解期予健脾补肺化痰方口服,总疗程为6月,观察2组患儿治疗前后C-ACT,ECP,IgE的变化情况。并选取30例健康儿童作健康对照。结果治疗组和对照组发作期治疗前血清ECP,IgE水平差异无统计意义(P>0.05),治疗后较治疗前差异有高度统计意义(P<0.01)。治疗组与对照组发作期治疗前、缓解期治疗前血清ECP,IgE水平与健康对照组比较差异有统计意义(P<0.05);治疗组缓解期治疗后与健康对照组比较差异无统计意义(P>0.05),对照组缓解期治疗后ECP与健康对照组比较仍有统计意义(P<0.05);治疗组与对照组缓解期治疗后IgE与健康对照组比较,差异无统计意义(P>0.05)。结论中药序贯治疗能改善支气管哮喘患儿的C-ACT评分,降低哮喘患儿体内异常增高的ECP,IgE水平;中药序贯治疗的作用机制可能是通过降低ECP,IgE水平,从而达到治疗哮喘的目的。Objective To observe the effect of TCM sequential therapy on asthma control test to children（ C-ACT） score,serum eosinophile cationic protein（ ECP）,immunoglobulin protein E（ IgE） level in children bronchial asthma,and to explore the mechanism of TCM sequential therapy in the treatment of children with asthma.Methods 60 children with bronchial asthma were randomly divided into 2 groups,30 cases in each group. Control group in acute exacerbation inhaled fluticasone. Treatment group was given Wenfei Zhike Pingchuan Fang in acute stage,given Jianpi Bufei Huatan Fang in remission stage.The total course was 6 months.The C-ACT,ECP,IgE was recorded before and after treatment. And 30 healthy children were selected as healthy control group. Results Between the 2 groups before treatment,there was no statistical significance in IgE level,serum ECP（ P〉0.05）,but there was statistical significance after treatment（ P〈0.01）. Before treatment,there was statistical significance between the treatment group and control group with healthy control group（ P0.05）.There was no statistical significance between treatment group and healthy control group after remission treatment（ P〉0.05）.There was statistical significance between treatment group and healthy control group in ECP level after remission treatment（ P〈0.05）.There was no statistical significance between treatment group and control group with healthy control group in IgE level after remission treatment（ P〉0.05）. Conclusion TCM sequential therapy can improve the C-ACT score,reduce ECP,IgE levels in children bronchial asthma,which might be the mechanism of TCM sequential therapy in treating bronchial asthma.

关 键 词：儿童支气管哮喘 儿童哮喘控制测试 嗜酸性粒细胞阳离子蛋白 免疫球蛋白E 中药序贯疗法 

分 类 号：R256.12[医药卫生—中医内科学]