微血管密度和血管生成拟态在子宫腺肌症中的表达及意义  

The expression and significance of microvascular density and angiogenesis mimicry in uterine adenomyosis

作　　者：王木森 孙春风 柳雅玲[2] 

机构地区：[1]东阿县人民医院,山东聊城252201 [2]泰山医学院病理学教研室,山东泰安271000

出　　处：《泰山医学院学报》2016年第7期745-747,共3页Journal of Taishan Medical College

摘　　要：目的探讨微血管密度和血管生成拟态在子宫腺肌症中的表达及意义。方法选取我院2012年10月至2014年10月间组织病理确诊子宫腺肌症患者40例作为观察组,再选取40例非子宫腺肌症子宫切除患者作为对照组。采用免疫组织化学S-P法,用CD31单克隆抗体对两组患者进行表达情况的标记分析。采用特殊染色PAS观察两组患者血管生成拟态存在情况。结果在观察组子宫腺肌症异位内膜、在位内膜和对照组内膜组织中,CD31标记的微血管密度分别为32.850、22.275和14.275.均数间经两两比较的q检验,任意两组间比较,均具有统计学意义(P<0.001)。三组经PAS染色,均未观察到血管生成拟态。结论在子宫腺肌症中,异位内膜、在位内膜、对照组内膜微血管密度依次降低。血管生成因素与异位内膜侵袭能力有着较为密切的关系,可能是促进子宫腺肌症异位内膜侵袭的重要因素。Objective： To investigate the microvascular density and angiogenesis mimicry in the expression and signifi- cance of uterine adenomyosis. Methods ： Forty patients with histopathologie diagnosis of uterine adenomyosis were selected as observation group in our hospital between 2012 and October 10, 2014, then 40 cases of adenomyosis uterine hysterectomy patients were selected as control group. Using immunohistochemical S-P method, CD31 monoclonal antibody expression of two groups of patients were analyzed. Special staining PAS was used to observe angiogenesis mimicry in both groups. Results： In the uterine adenomyosis ectopic endometrium and the lining in the endometrium in the observation group, and endometrial tissue in the control group in the organization, CD31 markers of microvascular density were 32. 850, 22. 275 and 14. 275, respectively. The mean between the two in the q test showed that the comparison between the two groups was statistically significant （P 〈 0. 001 ）. Angiogenesis mimicry was not observed in the three groups by PAS staining. Conclusion： In the uterine adenomyosis, ectopic endometrium, the lining in ectopic and microvascular density of the control reduced in turn. Angiogenic factors and ectopic endometrial invasive ability have a close relationship, which may be one of the important factors promoting ectopic endometrium invasion of uterine glands.

关 键 词：血管密度 血管生成拟态 免疫组化 

分 类 号：R711.71[医药卫生—妇产科学]