正交试验优选穿琥宁注射液与临床常用输液的配伍条件  

Study on the Stability of Potassium Dehydroandrograpolide Succinate Injection in Clinical Common Transfusion

作　　者：张艳芬[1] 

机构地区：[1]天津市武清区人民医院,天津301700

出　　处：《中国现代应用药学》2016年第9期1194-1198,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究穿琥宁注射液与临床常用输液的配伍条件。方法选择温度、光照、放置时间、溶媒种类4个影响因素,以穿琥宁含量、配伍液的p H值变化、不溶性微粒数为检测指标,同时考察不同条件下配伍液中穿琥宁有关物质的限度。结果在4 h内,穿琥宁注射液与5%葡萄糖注射液及0.9%氯化钠注射液可配伍使用,但不宜与5%的葡萄糖氯化钠注射液配伍。结论穿琥宁注射液与5%葡萄糖注射液及0.9%氯化钠注射液在4 h内可配伍使用,应尽量避免日光照射与高温环境。OBJECTIVE To investigate the compatibility conditions of potassium dehydroandrograpolide succinate injection combined with clinical common transfusion. METHODS Selected temperature, illumination, storage time and solvent as factor, the content of potassium dehydroandrograpolide succinate, p H value changes of the compatibility solution and the insoluble particles was used as indexes. The limits of the related substances of potassium dehydroandrograpolide succinate in the compatibility solution were also investigated. RESULTS In 4 h, potassium dehydroandrograpolide succinate injection could be combined with 5% glucose injection and 0.9% sodium chloride injection, and was incompatible with 5% glucose and sodium chloride injection. CONCLUSION Potassium dehydroandrograpolide succinate injection can be combined with 5% glucose injection and 0.9% sodium chloride injection in 4 hours. But should try to avoid sunlight exposure and high temperature environment.

关 键 词：正交试验 穿琥宁注射液 常用输液 配伍稳定性 有关物质 

分 类 号：R952[医药卫生—药学]