双官能团柱[5]芳烃的合成  

Synthesis of the Bi-functionalized Pillar[5]arene

作　　者：苏戈[1] 吴斗峰[1] 李巧伟[1] 侯军利[1] 

机构地区：[1]复旦大学化学系,上海200433

出　　处：《有机化学》2016年第9期2130-2135,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21422202;21572035)资助项目~~

摘　　要：以柱[5]芳烃为原料,发展了一种由氨基与酯基以及氨基和羧基双官能团衍生化柱[5]芳烃的合成方法,并通过1H NMR以及X射线单晶衍射实验对柱[5]芳烃中官能团的构象进行了研究.在这类柱[5]芳烃中,分子内氢键可以诱导骨架上的侧链发生内翻,使得侧链上的氨基位于柱[5]芳烃孔穴内,并且通过调节烷基链的长度可以控制氨基的位置.The method for the synthesis of bi-functionalized pillar[5]arenes with amino and ester groups or amino and carboxylic group has been developed. The conformation of the functional group of the pillar[5]arene was investigated by using 1H NMR and X-Ray experiments. The intramolecular hydrogen bonding induces the side-chain of the pillar[5]arene to introvert. And thus, the amino group points to the inside cavity of the pillar[5]arene backbone. The position of the amino group is adjustable by using alkyl chains with different length.

关 键 词：芳烃 双官能团化 合成 构象分析 

分 类 号：O625.1[理学—有机化学]