活动期不同中医证型溃疡性结肠炎患者血清干扰素和白细胞介素-4水平的变化  

Changes of IFN- γ and IL- 4 Levels in Patients with Ulcerative Colitis of Different TCM Syndromes during Active Period

作　　者：李丽萍[1] 

机构地区：[1]云南省曲靖市第一人民医院中医科,云南曲靖655000

出　　处：《中国药业》2016年第19期30-32,共3页China Pharmaceuticals

摘　　要：目的观察活动期不同中医证型溃疡性结肠炎患者血清干扰素(IFN-γ)和白细胞介素-4(IL-4)水平的变化。方法选取2012年9月至2015年12月收治活动期溃疡结肠炎患者96例,作为观察组,另选取同期健康体检者100例,作为对照组。制作溃疡型结肠炎中医证型调查表,通过临床表现,将观察组分为不同中医证型组,分析患者和健康者TNF-γ和IL-4水平变化。结果中医证型分布情况从大到小依次为湿热内蕴型26例(27.08%),脾胃虚弱型22例(22.92%),肝郁脾虚型18例(18.75%),气滞血瘀型14例(14.58%),脾肾阳虚型10例(10.42%),阴血亏虚型6例(6.25%);观察组患者IFN-γ水平显著高于对照组(P<0.05),观察组IL-4水平显著低于对照组(P<0.05);不同中医证型IFN-γ水平均显著高于对照组(P<0.05),IL-4水平均显著低于对照组(P<0.05),实证患者IFN-γ水平高于虚证和虚实夹杂证患者(P<0.05),虚证患者IL-4水平显著高于其他组(P<0.05)。结论不同中医证型溃疡性结肠炎患者均存在不同程度的细胞免疫功能紊乱,实证患者IL-4水平较低,活动期溃疡性结肠炎IL-4测定对临床分析有一定参考价值。Objective To analyze the changes of IFN-γ and IL-4 levels in patients with ulcerative colitis of different TCM syndromes during active period. Methods 96 patients with ulcerative colitis i from September 2012 to December 2015 were selected as the obser-vation group, 100 healthy volunteers were selected as the control group. Ulcerative colitis syndromes questionnaire was made. The obser-vation group was further divided into different TCM syndromes by clinical manifestations. Changes of the TNF-γ and IL-4 levels in the observation group and the control group were analyzed. Results TCM syndrome distribution in decreasing order of damp was 26 cases （ 27. 08% ） , spleen and stomach 22 cases （ 22. 92% ） , liver and spleen 18 cases （ 18. 75% ） , blood stasis type 14 cases （ 14. 58% ） , spleen deficiency 10 cases （ 10. 42% ） , Yin deficiency type 6 cases （ 6. 25% ） . IFN-γ level in the observation group were significantly higher than control group （ P 〈 0. 05 ） , IL-4 level in the observation group were significantly lower than the control group （ P 〈 0. 05 ） . IFN-γ levels in different TCM syndromes were significantly higher than the control group （ P 〈 0. 05 ） , and IL-4 levels were significantly lower than the control group （ P 〈 0. 05 ）;IFN-γ level in the evidence-based syndrome group was higher than the deficiency syndrome and combination group （ P 〈 0. 05 ）; IL-4 level in the deficiency syndrome group was significantly higher than other groups （ P 〈 0. 05 ） . Conclusion Different TCM syndrome ulcerative colitis patients have varied degrees of cellular immune dysfunction, the evidence-based syndrome group has lower IL-4 level. The IL-4 measurement during active period of ulcerative colitis has some reference value in clinical analysis.

关 键 词：溃疡性结肠炎 中医证型 血清干扰素 白细胞介素-4 

分 类 号：R241[医药卫生—中医诊断学] R574.62[医药卫生—中医临床基础]