丙泊酚对腹腔镜下子宫肌瘤剔除术患者全身麻醉苏醒期躁动的影响  

Effect of Propofol on Emergency Agitation during the Recovery Period of General Anesthesia in Patients Undergoing Laparoscopic Myomectomy

作　　者：黄洁[1] 蒋文琛[1] 

机构地区：[1]湖南省妇幼保健院麻醉手术科,湖南长沙410000

出　　处：《中国药业》2016年第19期50-53,共4页China Pharmaceuticals

摘　　要：目的探讨丙泊酚对腹腔镜下子宫肌瘤剔除术患者全身麻醉苏醒期躁动的影响。方法选取2015年9月至2016年7月收治的腹腔镜下子宫肌瘤剔除术治疗的子宫肌瘤患者82例,随机分为观察组和对照组,每组41例。观察组在建立气腹前给予丙泊酚与瑞芬太尼维持麻醉,对照组采用七氟烷吸入维持麻醉。观察并记录两组麻醉基本情况包括麻醉起效时间、恢复时间及拔管时间,比较两组抗躁动效果及苏醒期躁动发生情况,并检测躁动指标血清褪黑素浓度。结果两组麻醉起效时间比较无统计学意义(P>0.05);与对照组相比,观察组恢复时间、拔管时间显著较短,Ramsay镇静评分显著较高(P<0.05)。观察组躁动发生率为74.63%明显低于对照组的34.15%(P<0.05)。两组麻醉诱导前血清褪黑素浓度比较无统计学意义(P>0.05),对照组苏醒期血清褪黑素浓度明显降低(P<0.05),观察组显著高于对照组(P<0.05)。结论丙泊酚对腹腔镜下子宫肌瘤剔除术患者全身麻醉苏醒期抗躁动效果较好,可明显减少患者躁动,且可缩短恢复及拔管时间。Objective To investigate the effect of propofol on emergency agitation during the recovery period of general anesthesia in patients undergoing laparoscopic myomectomy. Methods 82 patients with uterine fibroids who underwent laparoscopic myomectomy in the hospital from September 2015 to July 2016 were selected and randomly divided into the observation group and the control group, 41 cases in each group. The observation group was given propofol and remifentanil maintenance anesthesia before the establishment of pneumoperitoneum, while the control group was given sevoflurane inhalation maintenance anesthesia. The basic situation of anesthesia in the two groups were observed and recorded, including the onset time of anesthesia, recovery time and extubation time. The anti- agitation effect and the occurrence of emergency agitation during the recovery period between the two groups were compared. The concentration of agitation index serum melatonin was detected. Results There was no significant difference in onset time of anesthesia between the two groups（ P 〉 0.05）. Compared with the control group, the recovery time and extubation time of observation time were significantly shor- ter, and the Ramsay sedation score was significantly higher（P 〈 0.05）. The incidence of agitation in the observation group （74.63%） was significantly lower than that in the control group （34. 15% ）（P 〈 0. 05）. There was no significant difference in the concentration of serum melatonin between the two groups before anesthesia induction（P 〉 0. 05）. The concentration serum melatonin in control group was significantly decreased in recovery period（ P 〈 0.05）, and the concentration serum melatonin in observation group was significantly higher than that in control group（ P 〈 0.05 ）. Conclusion The anti- agitation effect of propofol in the recovery period of general anes- thesia in patients undergoing myomectomy is good. It can significantly reduce the agitation, and can shorten the recovery time and extu- b

关 键 词：丙泊酚 腹腔镜 子宫肌瘤剔除术 苏醒期躁动 

分 类 号：R969.4[医药卫生—药理学] R971.1[医药卫生—药学]