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作 者:黄磊[1] 张卫星[1] 陈映群[1] 张声[1] 陈晶莹[1] 李伟佳[1] 昌晓寒[1]
机构地区:[1]北京大学深圳医院重症医学科,广东省深圳518036
出 处:《中国基层医药》2016年第19期2969-2972,共4页Chinese Journal of Primary Medicine and Pharmacy
摘 要:目的:分析严重感染和感染性休克患者病死的危险因素。方法142例 ICU 严重感染和感染性休克患者,根据住院预后情况分为存活组(98例)和死亡组(44例),采用二分类 Logistic 回归分析确立严重感染和感染性休克的病死危险因素。结果强心药使用(OR =4.329,95%CI:1.045-17.937,P =0.043)、血糖>10 mmol/L(OR =3.771,95%CI:1.214-11.710,P =0.022)和 APACHE Ⅱ评分(OR =3.098,95%CI:2.012-4.760,P =0.000)是住院死亡的独立危险因素(P <0.05),早期目标治疗(early goal-directed therapy, EGDT)后氧合指数增高是住院死亡的保护因素(OR =0.682,95%CI:0.500-0.930,P =0.016)。结论严重感染和感染性休克患者使用强心药、血糖>10 mmol/L、APACHE Ⅱ评分高及 EGDT 后氧合指数下降提示患者预后不良。Objective To study the risk factors of mortality in severe sepsis and septic shock patients. Methods 142 patients with severe sepsis and septic shock in ICU were observed and divided into alive group (98 patients)and dead group (44 patients)by using hospital mortality.The risk factors of mortality in severe sepsis and septic shock patients were assessed by binary logistic regression.Results Independent mortality risk factors were inotropic agents (OR =4.329,95%CI:1.045 -17.937,P =0.043),blood glucose 〉10 mmol/L (OR =3.771,95%CI:1.214 -11.710,P =0.022)and APACHE Ⅱ score (OR =3.098,95%CI:2.012 -4.760,P =0.000),while PaO2 /FiO2 after early goal -directed therapy (EGDT)was protective factor (OR =0.682,95%CI:0.500 -0.930, P =0.016).Conclusion Severe sepsis and septic shock patients with inotropic agents,blood glucose 〉10mmol/L, high APACHE Ⅱ score and decreased PaO2 /FiO2 after EGDT indicate poorly prognosis.
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