白细胞介素33及其受体在系统性红斑狼疮患者表达研究  

Expressions of IL-33 and Its Receptor in Patients with Systemic Lupus Erythematosus

作　　者：周厚清[1] 张彦鹏[1] 郭岱琦[1] 

机构地区：[1]深圳市第二人民医院,广东深圳518036

出　　处：《现代诊断与治疗》2016年第15期2747-2749,共3页Modern Diagnosis and Treatment

基　　金：深圳市科技计划项目(JCYJ20140414170821154)

摘　　要：目的明确白细胞介素33(IL-33)及IL-33受体(IL-33R)在系统性红斑狼疮(SLE)发病过程中的作用。方法酶联免疫吸附试验(ELISA)技术检测系统性红斑狼疮(SLE)患者和性别年龄匹配组对照人群血清IL-33表达水平,应用流式细胞方法检测外周血白细胞表面IL-33受体(IL-33R)表达水平。共检测140例SLE患者和140例正常对照者。参照美国风湿病学会1997年修订的标准判定SLE。结果 SLE患者血清IL-33表达水平明显高与正常对照者,显示出明显的相关性。各细胞亚群表面的IL-33R(ST2)表达水平在SLE和正常对照组中相似,在CD4+、CD14+和CD19+等细胞亚群内IL-33R表达没有显著差异,但SLE患者CD8+细胞亚群内IL-33R表达明显高于对照组。结论IL-33在系统性红斑狼疮发病过程中可能具有重要的作用。Objective Clarifying the role of IL-33 and its receptor IL-33R in the pathogenesis of human systemic lupus erythematosus （SLE）. Methods ELISA method was used to detect serum IL-33 levels and IL-33R （ST2） expression levels on leukocytes were detected by Flow Cytometry. Expressions of IL-33 and IL-33R were detected in 140 SLE patients and 140 healthy controls. Results Serum IL-33 levels were significant higher in SLE patients than that in control, and SLE patients expressed significant higher IL-33R levels on CD8＋ cells groups,however no differ-ence of IL-33R expression was found on CD4＋ cells, CD14＋ cells and CD19＋cells groups. Conclu-sion IL-33 and its receptor may play an important role in thepathogenesis of lupus nephritis.

关 键 词：系统性红斑狼疮 白细胞介素33 白细胞介素33受体 

分 类 号：R593.24[医药卫生—内科学]