全身化疗联合支气管动脉化疗栓塞术治疗老年晚期肺鳞癌的疗效观察  

Observation on Efficacy of Systemic Chemotherapy Combined with Bronchial Artery Chemoembolization in Treatment of Elderly Patients with Advanced Lung Squamous Cell Carcinoma

作　　者：曹玉娟[1] 曹凤[1] 王德林[1] 何山[1] 魏佳[2] 曹邦伟[2] 

机构地区：[1]北京大学首钢医院肿瘤科,北京100041 [2]首都医科大学附属北京友谊医院肿瘤科,北京100050

出　　处：《中国医院用药评价与分析》2016年第9期1156-1158,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金资助(No.81272615)

摘　　要：目的:探讨全身化疗联合支气管动脉化疗栓塞术治疗老年晚期肺鳞癌的临床疗效及安全性。方法:选取2011年1月—2013年12月住院治疗的93例老年晚期肺鳞癌患者,采用SAS 8.1 PROCPLAN程序以1∶1的比例生成随机分配序列,随机分为2组。治疗组患者(48例)采用全身化疗联合支气管动脉化疗栓塞术进行治疗,对照组患者(45例)行全身静脉化疗治疗。观察2组患者的治疗效果及不良反应发生情况。结果:治疗后,治疗组患者的客观有效率明显优于对照组[56.25%(27/48)vs.44.44%(20/45)],卡氏评分明显优于对照组[(83.8±8.7)分vs.(75.7±8.2)分],疾病控制率明显优于对照组[87.50%(42/48)vs.80.00%(36/45)],1年生存率明显高于对照组[85.33%(41/48)vs.73.67%(33/45)],2年生存率明显高于对照组[45.77%(22/48)vs.40.67%(18/45)],差异均有统计学意义(P<0.05)。2组患者发生的不良反应多为骨髓抑制及恶心呕吐,均可耐受;其中治疗组患者中性粒细胞减少症、贫血及恶心呕吐的发生率明显低于对照组,差异有统计学意义(P<0.05);没有治疗相关死亡病例,且治疗组患者未出现介入治疗相关并发症。结论:全身化疗联合支气管动脉化疗栓塞术可显著改善老年晚期肺鳞癌患者的临床症状,提高近期生存率,其不良反应均可耐受。OBJECTIVE： To probe into the clinical efficacy and safety of systemic chemotherapy combined with bronchial artery chemoembolization in treatment of elderly patients with advanced lung squamous cell carcinoma.METHODS： 48 patients with advanced lung squamous cell carcinoma admitted from Jan. 2011 to Dec. 2013 were selected as the observation group,and the patients were treated with systemic chemotherapy combined with bronchial artery chemoembolization; 45 patients receiving systemic chemotherapy were set as the control group. The treatment effects and incidence of adverse drug reactions of two groups were observed. RESULTS： After treatment,the objective effective rate,Karnofsky score,disease control rate,one-year survival rate,two-year survival rate in observation group were significantly higher than those of control group [56. 25%（ 27 /48） vs. 44. 44%（ 20 /45） ],[（ 83. 8 ± 8. 7） scores vs.（ 75. 7 ± 8. 2） scores],[87. 50%（ 42 /48） vs. 80. 00%（ 36 /45） ],[85. 33%（ 41 /48） vs. 73. 67%（ 33 /45） ]and [45. 77%（ 22 /48） vs. 40. 67%（ 18 /45） ],with statistically significant difference（ P〈0. 05）. The adverse drug reactions of two groups were mainly myelosuppression and nausea and vomiting,were well tolerable; among which the incidence of neutrophilic granulocytopenia,anemia and nausea and vomiting in observation group were significantly lower than those in control group,with statistically significant difference（ P〈0. 05）. There were no associated deaths,and no complications in observation group induced by interventional therapy. CONCLUSIONS： Systemic chemotherapy combined with bronchial artery chemoembolization in treatment of elderly patients with advanced lung squamous cell carcinoma can significantly improve the clinical symptoms,increase the short term survival rate and the adverse drug reactions were tolerable.

关 键 词：晚期肺鳞癌 化疗 支气管动脉化疗栓塞术 

分 类 号：R979.1[医药卫生—药品]