Pleiotropic Effects of Herbs Characterized with Blood-Activating and Stasis-Resolving Functions on Angiogenesis  

作　　者：陶丽 王生 赵杨 王爱云 张蕾 阮君山 范方田 刘玉萍 李尧 岳志强 钱文慧 陈文星 陆茵 

机构地区：[1]Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine [2]Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine [3]Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University [4]Fujian Provincial Hospital, Clinical College of Fujian Medical University [5]Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine [6]Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine

出　　处：《Chinese Journal of Integrative Medicine》2016年第10期795-800,共6页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos.81173174,81403260 and 81573859);China Post-doctoral Science Foundation(No.2014M551639);Natural Science Foundation of Jiangsu Province(No.BK2012854);Postdoctoral Funding in Jiangsu Province(No.1401138C);2013 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education(No.PPZY2015A070);the Priority Academic Program Development of Jiangsu Higher Education Institutions;Jiangsu College Graduate Research and Innovation Projects(No.CXZZ13_0627)

摘　　要：Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that （1） BASR-CM might emphasize on a balanced multi-cytokines network interaction; （2） BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; （3） BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.Accumulative evidences have underpinned the nature candidates from Chinese medicine （CM）, particularly CM served as blood activating and stasis resolving （BASR, Huoxue Huayu in Chinese） by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that （1） BASR-CM might emphasize on a balanced multi-cytokines network interaction; （2） BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; （3） BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.

关 键 词：blood activating and stasis resolving Chinese medicine pro-angiogenesis anti-angiogenesis physiological angiogenesis pathological angiogenesis ARTERIOGENESIS 

分 类 号：R285[医药卫生—中药学]