幽门螺杆菌感染与2型糖尿病并发症的关系  

Relationship between Helicobacter pylori infection and type 2 diabetes complications

作　　者：朱春英[1] 张英福[2] 马静静[1] 杨茜[1] 郭淑芹[3] 李志红[1] 

机构地区：[1]保定市第一中心医院内分泌二科,河北省保定市071000 [2]保定市第一中心医院内镜室,河北省保定市071000 [3]保定市第一中心医院内分泌科,河北省保定市071000

出　　处：《世界华人消化杂志》2016年第26期3799-3803,共5页World Chinese Journal of Digestology

摘　　要：目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与2型糖尿病并发症之间的关系,为防治并发症提供依据.方法于我科住院的131例2型糖尿病患者,均行胃黏膜组织切片染色确定H.pylori感染,分为H.pylori阳性组62例,H.pylori阴性组69例,通过血管彩超确定糖尿病性血管病变、尿微量白蛋白(the urine trace albumin,ALB)及24 h尿蛋白定量确定糖尿病性肾病、依据眼科眼底检查确定糖尿病性视网膜病变以及肌电图或临床神经病变症状确定糖尿病性周围神经病变.观察H.pylori与糖尿病并发症的关系.结果H.pylori阳性组中糖尿病性血管病变、糖尿病性肾病、糖尿病性周围神经病变发病率依次为62.9%、27.4%、56.4%,与H.pylori阴性组比较差异有统计学意义(P<0.05).H.p y l o r i阳性组中A L B及24 h尿蛋白明显高于H.pylori阴性组,差异具有统计学意义(P<0.05).结论H.pylori与糖尿病性血管病变、糖尿病性肾病及糖尿病性周围神经病变关系密切,积极抗H.pylori治疗,辅助降低糖尿病并发症的发生、发展具有十分重要的意义.AIM To investigate the relationship between Helicobacter pylori（H.pylori） infection and type2 diabetes complications,to provide guidance for prevention and treatment of diabetes complications.METHODS One hundred and thirty-one patients with type 2 diabetes who underwent gastric mucosa biopsy staining to determine H.pylori infection were divided into an H.pylori positive group（n- 62） and an H.pylori negative group（n-69）.Diabetic vascular lesions were diagnosed by color Doppler ultrasound,diabetic nephropathy was diagnosed by the urine trace albumin（ALB） and 24 h urinary protein test,diabetic retinopathy diagnosed by ophthalmic fundus examination,and diabetic peripheral neuropathy by electromyography or clinical symptoms.The relationship between H.pylori infection and the above-mentioned diabetes complications was then analyzed.RESULTS In the H.pylori positive group,the incidence rate of diabetic vascular lesions was 62.9%,the incidence rate of diabetic nephropathy was 27.4%,and the incidence rate of diabetic peripheral neuropathy was 56.4%,all of which were significantly higher than those of the H.pylori negative group（P 0.05）.ALB and 24 h urinary protein in the H.pylori positive group were significantly higher than those of the H.pylori negative group（P 0.05）.CONCLUSION There is a close relationship between H.pylori infection and diabetic vascular lesions,diabetic nephropathy,and diabetic peripheral neuropathy.Anti-H.pylori treatment can help reduce the occurrence and development of diabetic complications.

关 键 词：2型糖尿病 并发症 幽门螺杆菌 

分 类 号：R587.2[医药卫生—内分泌]