Rational design and functional evolution of targeted peptides for bioanalytical applications  

作　　者：Yanyan Huang Yulong Jin Rui Zhao 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems,Institute of Chemistry, Chinese Academy of Sciences [2]University of Chinese Academy of Sciences

出　　处：《Science China Chemistry》2016年第10期1250-1257,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (21375134, 21475140, 21135006, 21321003);The National Basic Research Program of China (2015CB856300);the Chinese Academy of Sciences

摘　　要：The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles.In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles. In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.

关 键 词：PEPTIDE DESIGN SCREENING targeted analysis biomedical applications 

分 类 号：R392[医药卫生—免疫学] O629.72[医药卫生—基础医学]