Mkx(Mohawk)在肌腱组织工程中的应用与作用  

Role of Mkx(Mohawk) in tendon tissue engineering

作　　者：李丹 郭杏 谭美云 

机构地区：[1]西南医科大学附属医院整形烧伤外科,四川省泸州市646000 [2]西南医科大学附属医院骨与关节外科,四川省泸州市646000

出　　处：《中国组织工程研究》2016年第37期5580-5587,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(31271049)~~

摘　　要：背景:近年来研究证实转录因子Mkx(Mohawk)是肌腱形成、发育、分化的关键因子之一。目的:总结Mkx的分子结构、分布、功能以及在肌腱分化过程中的信号通路等方面的研究进展。方法:用计算机检索维普数据库(1990至2016年)、中国期刊全文数据库(1990至2016年)及Medline数据库(1990至2016年),检索词分别为"Mkx;Mohawk;Irxl;肌腱;成肌腱分化;组织工程;转化生长因子β;干细胞;和"Mkx;Mohawk;Irxl;tendon;tendon differentiation;tissue engineering;TGFβ;stem cell"。检索有关转录因子Mkx(Mohawk)在肌腱组织工程中的研究进展,最终保留55篇文献。结果与结论:转录因子Mkx在肌腱形成发育及组织工程肌腱的形成过程中发挥重要作用。Mkx在多种中胚层来源组织细胞中表达,Mkx发挥作用的途径虽不直接作用于Scx(Scleraxis),但可间接调控转化生长因子β2信号通路来调控肌腱祖细胞的分化,而干细胞的物种来源和不同细胞系以及不同细胞因子均对Mkx在肌腱组织工程中发挥作用有不同的影响。BACKGROUND： Mkx（Mohawk, transcription factor） is one of the crucial factors in tendon formation, development and differentiation.OBJECTIVE： To summarize the molecular structure, distribution and function of Mkx and its research process in the signaling pathways during tendon differentiation. METHODS： The first author retrieved the databases of Cq Vip, CNKI and Medline from1990 to 2016 using the keywords of ＂Mkx, Mohawk, Irxl, tendon, tendon differentiation, tissue engineering, TGFβ, stem cell＂ in Chinese and English, respectively. The articles related to research process of Mkx in tendon tissue engineering were retrieved, and a total of 55 literatures were enrolled finally. RESULTS AND CONCLUSION： Mkx that expresses in various mesoderm-derived tissues plays an important role in the formation and development of tendon and tissue-engineered tendon formation. Although Mkx does not directly act on Scx（Scleraxis）, it can regulate the differentiation of tendon progenitor cells via transforming growth factor-β2 signaling pathway. Cells from different species and different cell lines as well as various cytokines for certain make different effects on Mkx involved in tendon tissue engineering.

关 键 词：腱 干细胞 转录因子 组织构建 组织工程 肌腱 Mohawk Irxl 成肌腱分化 转化生长因子Β 间充质干细胞 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]