社区获得性肺炎患者不同类型标本呼吸道病毒混合感染情况  

Co-infection of respiratory viruses in different types of samples in patients with community-acquired pneumonia

作　　者：董晓春[1] 李琳[1] 孔梅[2] 李晓燕[2] 

机构地区：[1]天津市疾病预防控制中心传染病科,天津300011 [2]天津市疾病预防控制中心病原微生物检测所,天津300011

出　　处：《职业与健康》2016年第17期2378-2382,共5页Occupation and Health

基　　金：天津市卫生局科技基金项目(2013KZ049)

摘　　要：目的了解天津市社区获得性肺炎病毒病原构成以及混合感染情况,比较不同类型标本混合感染的检出率。方法在天津市3家医院,选取2013—2014年共201例社区获得性肺炎患者,同时采集咽拭子和其他呼吸道分泌物标本,采用多重逆转录-聚合酶链反应（RT-PCR）方法检测9类15种常见呼吸道病毒。结果呼吸道病毒阳性检出率为59.20%,混合感染率为22.39%,博卡病毒的混合感染占其阳性人次数的比例最高,为85.71%。不同年龄组混合感染占阳性比例的差异有统计学意义（χ~2=27.848,P=0.01）。鼻咽抽吸物的阳性检出率和混合感染率均高于咽拭子（χ~2值分别为48.490和37.500,均P〈0.05）。结论引起天津地区社区获得性肺炎的病毒病原存在一定程度的混合感染,鼻咽抽吸物标本的混合感染检出率较高。[Objective]To survey the virus etiology and co-infection of community-acquired pneumonia in Tianjin,compare the coinfection rate in different types of samples. [Methods]Both throat swab and other respiratory samples from 201 patients with community-acquired pneumonia in 3 hospitals of Tianjin were collected to detect 15 respiratory virus by RT-PCR from 2013-2014.[Results]The detection rate of respiratory viruses was 59.20% and co-infection rate was 22.39%. The co-infection of Bocavirus accounted for the largest proportion of the positive cases,which was 85.71%. There was significant difference in the proportion of coinfection cases to positive cases among different age group（χ~2 =27.848,P =0.01）. The detection rate and co-infection rate of nasopharyngeal aspiration were higher than those of throat swab（χ~2=48.490,χ~2=37.500,P〈0.05）. [Conclusion]There is the coinfection of respiratory virus for community-acquired pneumonia in Tianjin. The nasopharyngeal aspiration has a higher co-infection rate.

关 键 词：社区获得性肺炎 呼吸道病毒 标本类型 混合感染 

分 类 号：R183[医药卫生—流行病学]