2型糖尿病患者血清同型半胱氨酸水平与认知功能关系的研究  

Study on the correlation between homocysteine concentration of type 2 diabetic patients and cognitive function

作　　者：任占云[1] 王亮亮[1] 汤武装 赵彦平[1] 

机构地区：[1]江苏大学附属宜兴医院,214200

出　　处：《齐齐哈尔医学院学报》2016年第21期2625-2628,共4页Journal of Qiqihar Medical University

基　　金：宜兴市社会发展科技项目(2014-19)

摘　　要：目的探讨2型糖尿病患者血清同型半胱氨酸水平与认知功能障碍之间的关系。方法选择2型糖尿病(T2DM)患者60例为研究对象,根据血清同型半胱氨酸(Hcy)水平是否正常分两组:血清同型半胱氨酸正常为2型糖尿病组1,血清同型半胱氨酸异常为2型糖尿病组2。健康体检者30例为对照组。选用简易智能精神状态检查量表(MMSE)及蒙特利尔认知评估(MoCA)对研究对象及对照组进行认知功能评估。结果 2型糖尿病患者血清同型半胱氨酸水平较对照组明显增加(P<0.05),2型糖尿病患者MMSE评分及MoCA评分均与血清同型半胱氨酸水平均呈负相关(P均<0.05)。2型糖尿病患者与健康对照比较在注意和计算力、记忆力、语言,执行方面功均存在功能障碍(P均<0.05),合并高同型半胱氨酸患者还存在物体命名功能障碍(P<0.05)。结论 2型糖尿病患者血清同型半胱氨酸水平明显增加,且与认知功能障碍程度呈负相关。Mo CA在早期发现认知障碍方面较MMSE更加敏感。2型糖尿病合并高同型半胱氨酸患者除注意和计算力、记忆力、语言,执行方面功能均存在功能障碍,还存在物体命名功能障碍。Objective To investigate the correlation between homocysteine levels of type 2 diabetic patients and cognitive dysfunction.Methods 60 patients with Type 2 diabetes mellitus（T2DM） were enrolled in the study,according to serum homocysteine（ Hcy） levels they were divided into two subgroups： normal serum homocysteine group,abnormal serum homocysteine group. 30 cases those who went for health examination were enrolled in the control group. Mini- mental- state examination（ MMSE） and Montreal Cognitive Assessment（ Mo CA） were used to carry out cognitive function assessment. Results Homocysteine levels in type 2 diabetic patients significantly higher than the control group（ P〈0.05）. Mo CA and MMSE score were negatively correlated with serum homocysteine levels（ P〈0.05）. Type 2 diabetes patients present dysfunction in comparison attention and computing power,memory,language,the implementation of the work compared with healthy controls（ P〈0.05）. Type 2 diabetes patients with homocysteine had dysfunction of name object（ P〈0. 05）. Conclusions The serum homocysteine levels in diabetic type 2 increased significantly and negatively correlated with the degree of cognitive dysfunction. Mo CA is more sensitive than the MMSE in early detect cognitive obstacles. Type 2 diabetes patients with high homocysteine not only have dysfunction in attention and computing power,memory,language,implementation of the functions are present dysfunction,but also have name object dysfunction.

关 键 词：2型糖尿病 同型半胱氨酸 认知功能障碍 

分 类 号：R714.246[医药卫生—妇产科学]