神经节苷脂钠辅助治疗老年重症脑卒中患者的疗效及对患者血液流变学、生活质量的影响  

Effect of Ganglion glycosides sodium adjuvant therapy on elderly patients with severe stroke and its effect on Hemorheology and quality of life

作　　者：谢靖[1] 

机构地区：[1]石河子大学医学院第一附属医院神经内科,新疆维吾尔自治区832008

出　　处：《齐齐哈尔医学院学报》2016年第21期2636-2638,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨神经节苷脂钠辅助治疗老年重症脑卒中患者的疗效及对患者血液流变学、生活质量的影响。方法选择2014年8月至2015年8月本院收治的老年重症脑卒中患者84例,将其随机分为观察组45例、对照组39例,对照组给予常规治疗方案,观察组患者在对照组基础上给予神经节苷脂钠注射液静脉注射,两组均以治疗8周为一个疗程,比较两组治疗前后神经功能缺损评分(NIHSS)、血液流变学以及生活质量变化情况。结果治疗前两组患者NIHSS评分无显著差异(P>0.05),治疗后两组患者NIHSS评分显著降低(P<0.05),且治疗后观察组患者NIHSS评分显著低于对照组(P<0.05);两组患者治疗前全血高切黏度、全血低切黏度以及红细胞沉降率均无显著差异(P>0.05),治疗后两组患者全血高切黏度、全血低切黏度均显著降低(P<0.05),红细胞沉降率均显著升高(P<0.05),且治疗后观察组患者全血高切黏度、全血低切黏度低于对照组(P<0.05),红细胞沉降率显著高于对照组(P<0.05);治疗后观察组患者日常生活、活动能力、生活感受、健康感受以及生活质量总分均显著高于对照组(P<0.05)。结论神经节苷脂钠辅助治疗老年重症脑卒中患者,能够有效改善患者的神经功能缺损情况,并有效改善患者的血液流变学、提高患者的生活质量。Objective To investigate the effect of ganglion glycosides sodium in the treatment of patients with severe stroke and the effect on the quality of life and Hemorheology. Methods 84 cases of elderly patients with severe stroke patients admitted to our hospital during August 2014 and August 2015,they were divided into observation group（ 45 cases） and control group（ 39 cases）,patients in the control group received conventional therapy,while patients in observation group received ganglioside sodium injection for intravenous injection on the basis of the control group,8 weeks as a course of treatment for both of the two groups,the neural function defect score（ NIHSS）,blood rheology study and the change of quality of life were compared.Results The NIHSS score of the two groups had no significant difference before treatment（ P〉0.05）. NIHSS scores of both groups decreased significantly after treatment（ P〈0.05）,and NIHSS scores in observation group were significantly lower than the control group（ P〈0.05）. To the aspect of Hemorheology,high blood viscosity,low blood viscosity and erythrocyte sedimentation rate of the two groups of patients before treatment had no significant difference（ P〉0. 05）. After treatment,high blood viscosity and low blood viscosity of the two groups decreased significantly（ P〈0.05）,and red blood cell rate significantly increased after treatment（ P〈0.05）. High blood viscosity and low blood viscosity of the observation group lower than that of the control group after treatment（ P〈0. 05）,and the erythrocyte sedimentation rate of observation group was significantly higher than the control group（ P〈0.05）. After treatment,patients in the observation group,activities of daily life,feelings of life,health and life experience the total score of living quality were significantly higher than that of the control group（ P〈0. 05）. Conclusions Ganglion glycosides sodium auxiliary treatment of elderly patients with severe stroke,can effectively impr

关 键 词：神经节苷脂钠 重症脑卒中 血液流变学 生活质量 老年患者 

分 类 号：R473.74[医药卫生—护理学]