解偶联蛋白2调控机制及实验研究进展  

Uncoupling protein 2 in regulatory mechanisms and basical experiments

作　　者：陈亦婷[1] 曾其毅[1] 

机构地区：[1]南方医科大学珠江医院儿科,广州510282

出　　处：《国际儿科学杂志》2016年第9期700-703,共4页International Journal of Pediatrics

基　　金：国家自然科学基金（81272070）

摘　　要：线粒体解偶联蛋白UCP2为线粒体内膜质子转运蛋白，通过介导“质子漏”，氧化磷酸化轻度解偶联，降低线粒体膜电位，减少线粒体ROS产生，保护线粒体功能。线粒体解偶联蛋白由于其内源性抗氧化作用而被多个领域研究。该文就UCP2调控机制及其实验研究进展作一综述。Uncoupling protein 2（UCP2）is a proton transporter which presents in the mitochondrial inner membrane. Recent studies have found that UCP2 plays important roles in protecting mitochondria functions,re-ducing mitochondrial ROS generation by inducing proton leak across the inner mitochondrial membrane and pro-moting mild uncoupling which leading to a decrease in the mitochondrial inner membrane′s potential. Because of its antioxidant function,UCP2 has been studied in several domains. This review provides novel insights into the molecular mechanisms,by which the activity of UCP2 is regulated and describe novel findings concerning basical experiments of UCP2.

关 键 词：解偶联蛋白2 线粒体 氧自由基 脓毒症 

分 类 号：R3411[医药卫生—基础医学]