雷替曲塞奥沙利铂肝动脉灌注栓塞与静脉给药治疗结直肠癌肝转移的疗效及安全性比较  

Comparison of efficacy and safety of raltitrexed and oxaliplatin transcatheter hepatic arterial chemoembolization and intravenous administration in the treatment of liver metastasis of colorectal cancer

作　　者：王新林[1] 宋锦文[1] 魏璇[1] 刘彩霞[1] 王湘辉[1] 张金国[1] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050

出　　处：《现代肿瘤医学》2016年第21期3440-3442,共3页Journal of Modern Oncology

摘　　要：目的:比较雷替曲塞奥沙利铂肝动脉灌注栓塞与静脉给药治疗结直肠癌肝转移的疗效及安全性。方法:采用非盲法随机对照试验。试验组24例,雷替曲塞奥沙利铂肝动脉灌注栓塞,雷替曲塞3mg/m^2肝动脉灌注化疗15min以上,奥沙利铂130mg/m^2、碘化油(5~12)ml混合为混悬液进行栓塞10~15min,28天为1周期;对照组24例:雷替曲塞3mg/m^2,静脉滴注,15min以上,d_1,奥沙利铂130mg/m^2,静脉滴注,4h,d_1,28天为1周期。结果:试验组CR+PR 66.6%,TTP 10.5个月,对照组CR+PR 45.8%,TTP 4.5个月,两组相比差异有统计学意义(P<0.05);两组在毒副反应方面主要为血液学毒性和消化道反应,试验组优于对照组。结论:雷替曲塞奥沙利铂肝动脉灌注栓塞治疗结直肠癌肝转移相对于全身化疗毒副反应轻,其疗效确切是安全有效的一种治疗方案。Objective： To compare raltitrexed and oxaliplatin transcatheter hepatic arterial chemoembolization and venous curative for liver metastasis of colorectal cancer. Methods： To use non blinded randomized controlled trial ,24 cases were in test group trated by raltitrexed oxaliplatin combined with transcatheter hepatic arterial chemoembolization,raltitrexed 3mg/m2 hepatic artery infusion chemotherapy of oxaliplatin 130mg/m2 above 15min,（5 -12） ml mixed into mixed lipiodol embolization of 10 ~ 15min suspension,28days for 1 cycles. The control group 24 cases were treated by raltitrexed 3mg/m2,intravenous drip,15min above dl , oxaliplatin, 130mg/m2 , IV drip 4h ,d1 ,28days for 1 cycle. Results： In experimental group CR ＋ PR was 66. 6% , TTP 10. 5 months, CR ＋ PR was 45. 8% , in control group,TTP 4. 5 months,there was significant difference between two groups（P 〈0. 05） . In two groups adverse reactions mainly were hematological toxicity and gastrointestinal reaction, the test group was better than control group. Conclusion ： Raltitrexed and oxaliplatin combined with hepatic arterial infusion and embolization in treatment of liver metastasis of colorectal cancer toxicity of chemotherapy is light, its a safe and effective treatment.

关 键 词：雷替曲塞 奥沙利铂 肝动脉灌注栓塞 静脉治疗 结直肠癌肝转移 

分 类 号：R735.3[医药卫生—肿瘤]