黄连素对2型糖尿病患者血脂及胰岛素抵抗的影响及机制研究  

Berberine Blood Lipids in Patients with Type 2 Diabetes Mellitus and the Effect of Insulin Resistance and Mechanism Research

作　　者：王媛 

机构地区：[1]本溪市中心医院中西医结合科,辽宁本溪117000

出　　处：《糖尿病新世界》2016年第19期27-28,共2页Diabetes New World Magazine

摘　　要：目的探索黄连素治疗2型糖尿病患者血脂及胰岛素抵抗的影响及相关机制。方法采用随机、对照的方法将经临床确诊2型糖尿病的患者50例分为对照组和黄连素治疗组。结果与治疗前相比较,治疗组的FPG、胰岛素、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-c)、CRP和IL-6明显降低。同时,血清抗氧化应激关键酶SOD升高,MDA降低,差异有统计学意义(P<0.05)。结论黄连素能有效降低2型糖尿病患者血糖、血脂及胰岛素抵抗,机制可能与黄连素升高血清SOD、降低血清CRP、TNF-α及MDA水平,进而改善患者的微炎症及氧化应激状态。Objective To explore the berberine treatment in patients with type 2 diabetes blood fat and insulin resistance and related mechanisms. Methods Using randomized, controlled method 50 cases of clinically diagnosed type 2 diabetes patients were divided into control group and berberine in treatment group. Results Compared with before treatment, the treatment group of FPG, insulin, triglyceride （ TG）, cholesterol （ TC）, low density lipoprotein （ LDL-c）, CRP and IL-6 is de-creased obviously. At the same time, higher serum antioxidant stress key enzymes SOD, MDA decreased, the difference was statistically significant（ P〈0.05）. Conclusion Berberine can effectively reduce the patients with type 2 diabetes, blood sugar, blood fat and insulin resistance, the mechanism may be related to berberine increase serum SOD, lower the serum CRP, TNF alpha and MDA level, and improve the patient＇s state of micro inflammation and oxidative stress.

关 键 词：黄连素 2型糖尿病 血脂 胰岛素抵抗 疗效观察 

分 类 号：R587.1[医药卫生—内分泌]