个体化治疗狼疮性肾炎23例临床分析  

Individualized Treatment of 23 Patients with Lupus Nephritis Clinical Analysis

作　　者：胡义阳[1] 

机构地区：[1]福建省泉州市第一医院肾内科,福建泉州362000

出　　处：《中外医疗》2016年第28期63-65,共3页China & Foreign Medical Treatment

摘　　要：目的结合患者狼疮活动程度采取个体化治疗,评价使用环磷酰胺、糖皮质激素治疗狼疮性肾炎的临床效果与不良反应。方法方便抽取该院2013年4月—2014年4月收治的狼疮性肾炎患者23例作为该次研究对象,依据患者狼疮活动程度不同将其分为轻度活动组(5例)、中度活动组(8例)、重度活动组(10例)等3个小组,分别予以患者泼尼松片、环磷酰胺治疗,观察各组患者的实验室指标与不良反应。结果 3组患者接受个体化治疗后,其中有18例(78.2%)患者临床指标得到显著改善,不良反应明显减轻。3组该次治疗总有效率为78.2%;治疗后3组患者24 h尿蛋白、C3(g/L)、C4(g/L)、SCr(umol/L)等指标均有所改善,差异有统计学意义(P<0.05)。结论感染、白细胞下降、肝功能受损等并发症是狼疮性肾炎治疗过程中的常见并发症,临床治疗中需结合患者的实际病情采取个体化治疗,降低并发症发生率,减轻治疗中患者的不良反应。Objective To evaluate the clinical effect and adverse reaction of lupus nephritis treated with cyclophosphamide and glucocorticoids in combination with the degree of lupus activity in patients with individualized treatment. Methods Convenient selection 23 cases were selected in our hospital from April 2013 to April 2014 in patients with lupus nephritis as the research object, according to the different degree of lupus activity in patients with will the points to a mild activity group （5 cases）, moderate activity group （8 cases） and severe group （10 cases） and other three groups, which were treated with prednisone tablets, cyclophosphamide treatment, observation and adverse reaction of laboratory index of patients in each group. Results Three groups of patients after individual treatment, including 18 cases （78.2%） patients clinical indicators were significantly improved, the adverse reaction was significantly reduced. Three groups of the treatment of total effective rate was 78.2%. After treatment, the three groups of patients, 24 h urinary protein, （g / L） of C3 and C4 （ g/ L）, SCR （ umol/ L） and other indicators were improved, and the difference is statistically significant （P 〈 0.05）. Conclusion Infection, the decrease of white blood cells, liver function damage and other complications is common complication of lupus nephritis treatment process and clinical treatment for patients with actual condition take individualized treatment, reduce the inci-dence of complications, reduce adverse reaction in the treatment of patients.

关 键 词：狼疮性肾炎 环磷酰胺 临床效果 

分 类 号：R59[医药卫生—内科学]