脂蛋白相关磷脂酶A_2与原发性高血压患者发生缺血性卒中的相关性分析  

Correlation analysis of occurrence of ischemic stroke between lipoprotein-associated phospholipase A_2 and patients with essential hypertension

作　　者：来春林[1] 邢金平[1] 胡风云[2] 刘晓红[1] 齐杰[1] 赵建强[1] 冀友瑞[1] 杨五晓[1] 燕蒲娟 罗春艳[3] 阮露芳 

机构地区：[1]山西省人民医院心内科,太原030012 [2]山西省人民医院神经内科,太原030012 [3]山西医科大学研究生院

出　　处：《中国脑血管病杂志》2016年第9期455-459,共5页Chinese Journal of Cerebrovascular Diseases

基　　金：山西省社会发展基金(20120313018-8)

摘　　要：目的分析原发性高血压（EH）患者血清炎性因子脂蛋白相关磷脂酶A2（LP-PLA2）与缺血性卒中的关系,并探讨其临床意义。方法回顾性连续纳入符合纳入标准的EH患者167例,按照靶器官损伤（TOD）诊断标准分为单纯EH组79例,EH合并卒中组88例。测定每组入选对象的LP-PLA_2水平,比较各组间临床相关资料和LP-PLA_2水平的差异。采用多因素Logistic回归分析探讨LP-PLA_2水平对EH患者发生缺血性卒中的临床意义。结果 Logistic回归分析结果显示,LP-PLA_2是EH患者发生缺血性卒中的独立危险因素（OR=13.699,95%CI：5.236~35.837,P〈0.01）;在入选的危险因素中,LP-PLA_2的标化偏回归系数b＇绝对值最大（b＇=0.708）。结论 LP-PLA_2作为新型的炎性标记物,是缺血性卒中重要的独立危险因素,对EH患者发生缺血性卒中的影响最大,可能为脑血管事件的预防和治疗提供新方向。Objectives To analyze the relationship between serum inflammatory factor lipoproteinassociated phospholipase A_2（ LP-PLA_2） and ischemic stroke in patients with essential hypertension（ EH）and to investigate its clinical significance. Methods A total of 167 consecutive patients with EH met the inclusion criteria were enrolled retrospectively. According to the target organ damage（ TOD） diagnostic criteria,they were divided into either a simple EH group（ n = 79） or a EH combined stroke group（ n =88）. The LP-PLA_2 levels of the selected subjects in each group were detected. The differences of the clinical data and LP-PLA_2 levels were compared between the 2 groups. Multivariate Logistic regression analysis was used to investigate the clinical significance of LP-PLA_2 levels for EH patients occurring ischemic stroke.Results The results of Logistic regression analysis showed that Lp-PLA_2 was an independent risk factor for ischemic stroke in patients with EH（ OR,13. 699,95% CI 5. 236-35. 837,P〈0. 01）. In the selected risk factors,the absolute value was maximum in the standardized partial regression coefficient b＇ of Lp-PLA_2（ b＇ = 0. 708）. Conclusions As a new inflammatory marker,LP-PLA_2 is an important independent risk factor for ischemic stroke. It has the greatest impact on the occurrence of ischemic stroke in patients with EH. It may provide a new direction for the prevention and treatment of cerebrovascular events.

关 键 词：高血压 卒中 脂蛋白相关磷脂酶A2 原发性高血压 

分 类 号：R544.11[医药卫生—心血管疾病] R743.3[医药卫生—内科学]