银杏内酯治疗脑缺血作用机制的研究进展  

Research progress in pharmacological mechanism of ginkgolides against cerebral ischemia

作　　者：张学非 曹泽彧[1,2] 许治良[1,2] 李娜[1,2] 曹亮[1,2] 丁岗[1,2] 王振中[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中药制药过程新技术国家重点实验室,江苏连云港222001

出　　处：《中草药》2016年第16期2943-2948,共6页Chinese Traditional and Herbal Drugs

基　　金：国家科技部重大新药创制项目(2013ZX09402203)

摘　　要：脑缺血是严重威胁人类生命健康的疾病之一,其发病机制十分复杂,包括炎症反应、细胞凋亡、氧化应激、兴奋性神经毒性等。最近研究表明银杏内酯对脑部缺血损伤及组织再生修复有着一定治疗作用,对银杏内酯类化合物治疗脑缺血的作用机制及潜在靶点进行综述,并对临床常用药物进行了比较,以期阐明银杏内酯及其制剂治疗脑缺血的作用机制。Cerebral ischemia is a severe disease which threats people＇s health worldwide. The pathogenesis of cerebral ischemia is very complex, such as inflammatory reaction, apoptosis, oxidative stress, excitatory neurotoxicity, etc. Previous studies suggested that ginkgolides had a remarkable protective effect against the different types of brain injury including ischemia and tissue regeneration and repair. This review summarizes the targets of ginkgolides for cerebral ischemia treatments and the potential mechanisms. Compared with the commonly used drugs in clinic, we expect to clarify the mechanism of ginkgolides and their preparations in the treatment of cerebral ischemia.

关 键 词：脑缺血/再灌注 银杏内酯 作用机制 靶点 组织再生修复 

分 类 号：R285[医药卫生—中药学]