基于金属-有机骨架材料MIL-101的吗啡电化学传感器的研制  

Development of electrochemical sensor for morphine based on metal organic framework MIL-101

作　　者：张坤蕾 白茹燕 郑丽[1] 张茜[1] 李德蕾 胡蓉[1] 陈芮[1] 杨云慧[1] 

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《化学研究与应用》2016年第10期1433-1438,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21165023,21465026)资助

摘　　要：本文通过水热合成法合成一种金属-有机骨架材料(MOFs)——MIL-101,将其修饰在玻碳电极上制得电化学传感器(MIL-101/GCE)用于吗啡的快速灵敏检测。吗啡在MIL-101/GCE上的电化学行为用差分脉冲伏安法、循环伏安法来表征。在最佳条件下,测定吗啡的线性范围为1.5×10^(-6)~2.0×10^(-4)M,检测下限为5×10^(-7)M,相关系数为0.9911。将该传感器用于血清中吗啡的检测,回收率为101.7%,结果令人满意。说明该传感器有良好应用前景。In this paper, MIL-101 , a kind of metal organic frameworks（ MOFs） ,was synthesized using hydro-thermal method and modified onto the surface of glassy carbon electrode to prepare electrochemical sensor（ MIL-101/GCE） to detect morphine quickly and sensitively. The electrochemical behavior of morphine on the sensor（ MIL-101/GCE） was characterized by differential pulse vol-tammetry and cyclic voltammetry. Under the optimized conditions,linear range was froml. 5×10-6to 2. 0×10-4M with detection limit of 5 ×10-7M and the correlation coefficient of 0. 9911. The sensor was used to detect morphine in the serum sample. The recovery was 101. 7% , which is satisfied. The good testing results indicate that the MIL-101/GCE sensor has a great prospect in practical appli-cation.

关 键 词：金属有机骨架 吗啡 电化学传感器 

分 类 号：O657.1[理学—分析化学]