金纳米笼在肿瘤细胞光热治疗中的应用  

Application of gold nanocage(AuNC) in photothermal therap of tumor cell

作　　者：常贯儒[1,2] 朱军奇 鲁信勇 陈龙[1] 张海东[1] 

机构地区：[1]黄山学院化学化工学院,安徽黄山245041 [2]安徽大学化学化工学院,安徽合肥230601

出　　处：《化学研究与应用》2016年第10期1450-1455,共6页Chemical Research and Application

基　　金：安徽省教育厅自然科学研究重点项目(KJ2016A679)资助;安徽省高校优秀人才支持计划重点项目(gxyq ZD2016302)资助;省级大学科研创新训练项目(201510375048;AH201310375053)资助;黄山学院科研项目(2006xkjq007)资助;安徽大学研究生学术创新研究项目(yqh100053)资助

摘　　要：金纳米笼是一类新颖的光热转换材料,具有中空、多孔的特点,可吸收近红外波段(700~1200 nm)的光波,且光热转化效率高,可用于癌症的光热治疗。还具有良好的生物相容性,容易被多种生物分子修饰。本文以银纳米立方体作为模板剂,用氯金酸(HAuCl_4)置换方法制备金纳米笼。用红外热成像仪研究了在波长808nm、功率为200 m W·cm^(-2)的近红外激光辐射下金纳米笼的温度增加和光照效应。还研究了肿瘤细胞的细胞毒性和高热对肿瘤细胞的影响和细胞荧光成像。结果表明,金纳米笼表现出显著的光热作用,可用于光热切除癌细胞。Gold nanocage （AuNC） with the characteristics of hollow morphology and porosity,is a novel kind of photo-thermal con-version material,could absorb the near-infrared light （NIR） （700 ？1200 nm）,which is highly efficiently converted into heat for photothermal treatment of cancer. AuNC also has good biocompatibility, facile modification by a variety of biological molecules. Herein, AuNC was prepared via the galvanic replacement reaction between Ag nanocube template and HAuCl4 aqueous solution. The temperature increasement and photothermal effect under irradiation by an 808 nm NIR laser at a power density of 200mW· cm 2 were measured using an infrared thermal camera. The cytotoxicity, hyperthermia effect on tumor cells and fluorescence imaging were examined as well. The results demonstrate that AuNC show a remarkable photothermy and could be used for thermal ablation of cancer cells.

关 键 词：金纳米笼 光热治疗 荧光成像 治疗 红外热成像仪 

分 类 号：O614.12[理学—无机化学]