2-吡喃酮的合成新方法  

New method for preparation of 2-pyrones

作　　者：陈莉[1] 张勇[1] 王英特[1] 

机构地区：[1]山西大学化学化工学院,山西太原030006

出　　处：《化学研究与应用》2016年第10期1500-1504,共5页Chemical Research and Application

基　　金：山西省科协项目(2014SXSKX-03)资助;山西省回国留学人员科研资助项目(2015-001)资助

摘　　要：研究了α-烯酰基二硫缩烯酮与丙二酸单乙酯酰氯的成环反应,通过一步反应构建了2-吡喃酮骨架。考察了不同催化剂及用量等因素对反应的影响,并对反应的适用性进行了扩展,获得了较高的产率（80～88%）,为2-吡喃酮的合成提供了新方法。In this paper,the 2-pyrone skeleton by one-step cyclization between a-alkenoyl ketene-（5,5）-acetals and ethyl 3-chloro- 3-oxopropanoate was constructed. The effects of different catalysts and the amount of catalyst on this reaction were also studied. The experiment showed that this reaction had a good applicability of the different substrates and 2-pyrones were synthesized in high yields（80 ~88% ）. The simple procedure,mild condition,easy separation and high yield made this protocol attractive for synthesis of 2-pyrones.

关 键 词：丙二酸单乙酯酰氯 2-吡喃酮 α-烯酰基二硫缩烯酮 

分 类 号：O623[理学—有机化学]