Vδ2 γδ T细胞亚群在慢性HCV感染中的特征  

Characteristics of Vδ2 γδ T cells in patients with chronic hepatitis C

作　　者：殷文伟[1] 张琼方[1] 邵建营 童师雯[2] 

机构地区：[1]教育部感染性疾病分子生物学重点实验室,重庆医科大学病毒性肝炎研究所,重庆医科大学附属第二医院感染科,重庆400010 [2]重庆医科大学附属第二医院临床营养科,重庆400010

出　　处：《中国免疫学杂志》2016年第9期1346-1349,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81401664,81301423);中国博士后科学基金资助项目;重庆市博士后科学基金资助项目(Xm2014132);重庆市前沿与应用基础研究(一般)项目(cstc2015jcyjA10071)

摘　　要：目的:探讨γδT细胞及其亚群Vδ1和Vδ2 T细胞在慢性HCV感染中的作用。方法:采用流式细胞术检测人外周血γδT细胞及其亚群Vδ1和Vδ2 T细胞比例变化。结果:慢性HCV感染病人外周血中γδT细胞及其亚群Vδ1和Vδ2 T细胞比例与健康对照者相比无显著差异。相关性分析显示HCV感染患者Vδ2 T细胞数目与肝脏损伤成正相关而与病毒滴度不相关。慢性HCV感染病人Vδ2 T细胞处于活化状态,CD107a表达高于对照组。结论:Vδ2 T细胞亚群参与慢性HCV感染所致肝损伤。Objective：To study the role of γδ T cells and Vδ1 and Vδ2 T subsets played in patients with chronic hepatitis C.Methods：The percentage of peripheral blood γδ T cells and Vδ1 and Vδ2 T subsets cells was assessed by flow cytometry（FACS）.Results：There were no significant differences in the percentage of circulating γδ T cells and Vδ1 and Vδ2 T subsets between HCV-infected patients and healthy controls（HCs）.However,The number of peripheral blood Vδ2 T cells from HCV-infected patients was positively correlated with serum alanine aminotransferase（ALT） levels,but showed no correlation with serum HCV RNA.Peripheral Vδ2 T cells from HCV-infected patients were in activated status.The expression of CD107 a was enhanced in Vδ2 T cells from HCV-infected patients compared to HCs.Conclusion：Vδ2 T cells were involved in liver injury in chronic HCV-infected patients.

关 键 词：丙型肝炎病毒 ΓΔT细胞 Vδ2 T细胞 病毒滴度 谷丙转氨酶 

分 类 号：R512.63[医药卫生—内科学]