金华市住院感染患儿病原菌分布及产ESBLs细菌药敏分析  

Pathogenic Bacteria in Hospitalized Infectious Children in Jinhua City and Antibiotic Resistance Investigation of ESBLs Producing Bacteria

作　　者：周笑[1] 邱海燕[2] 徐建新[3] 应华永[3] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市妇女儿童医院,浙江宁波315200 [3]金华市中心医院,浙江金华321000

出　　处：《宁波大学学报（理工版）》2016年第4期117-122,共6页Journal of Ningbo University：Natural Science and Engineering Edition

摘　　要：为了解金华市感染患儿病原菌分布及产ESBLs细菌药敏情况,采用SPSS 18.0统计软件分析了金华某医院收集的住院感染患儿各类标本培养结果.结果发现：5年来总病原菌检出以革兰阴性菌为主,以肺炎克雷伯杆菌检出率最高,其中在0~1岁组检出率最高;各标本中,痰培养病原菌检出率最高,以肺炎克雷伯杆菌检出率最高,血培养以表皮葡萄球菌最高,尿培养以屎肠球菌最高;产ESBLs大肠埃希菌及肺炎克雷伯杆菌有逐年降低趋势;产ESBLs菌耐药率明显高于非产ESBLs菌,碳青霉烯类为首选药.分析表明病原菌在不同年龄及取样标本中分布各有特点,产ESBLs菌耐药率高,碳青霉烯类抗菌药仍为临床首选药物.In this paper, the pathogens in the infectious children are investigated, and the antibiotic resistance of ESBLs is analyzed： Each kind of cultivation in a Jinhua hospital is collected for analytical purposes. SPSS 18.0 is used for statistical analysis. The primary detection of pathogen in the past 5 years is found to be Gram-negative bacteria, and the highest detection rate is noted for Klebsiellia pneumonia. Within the age of 0-1, the main Pathogenic bacteria is Klebsiella pneumonia. The pathogen detection rate reaches the highest in the sputum culture. The main Pathogen in sputum culture is Klebsiella pneumonia. The main Pathogen in blood culture is Staphylococcus epidermidis. The main Pathogen in urine culture is identified to be Enterococcus faecium. Escherichia coli and KlebsieUa pneumonia of ESBLs producing have been decreasing on the annual basis. The antibiotic resistance of ESBLs producing bacteria is noted for being higher than that of nonproducing bacteria, and carbapenems is found to be the effective antibacterial drug. Conclusion can be reached that： the distribution of the pathogens can be characterized in relation to varying ages and specimen. The drug resistance rate of ESBLs producing bacteria is high, and the efficient drug is identified to be carbapenems.

关 键 词：儿童 感染 病原菌 超广谱Β-内酰胺酶 

分 类 号：R720.5[医药卫生—儿科]