5-氨基酮戊酸光动力疗法联合激光对尖锐湿疣效果  

ALA-PDT COMBINED WITH CO_2 LASER FOR CONDYLOMA ACUMINATA TREATMENT

作　　者：于文强[1] 张灵芝 于增照[1] 

机构地区：[1]青岛市市立医院皮肤科,山东青岛266011 [2]青岛市崂山区沙子口卫生院

出　　处：《青岛大学医学院学报》2016年第4期458-459,462,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)联合二氧化碳(CO_2)激光治疗尖锐湿疣的临床效果。方法将219例尖锐湿疣病人随机分为治疗组112例和对照组107例,均采用CO_2激光去除可见疣体。然后治疗组应用200g/L的5-ALA溶液局部湿敷,封包避光3~4h,最后应用XD-635AB型光动力治疗仪照射,功率260~300mW,照射剂量100J/cm^2,每次20min,每周1次,连续治疗4次。对照组局部外用干扰素凝胶,每天4次,共治疗4周。治疗后1、2、3及6个月时分别评价疗效。结果随访3个月后,治疗组97例临床治愈,治愈率为86.6%;对照组69例临床治愈,治愈率为64.5%,两组比较差异有显著性(χ2=14.597,P<0.05);随访6个月后,治疗组95例治愈,治愈率为84.8%;对照组66例治愈,治愈率为61.7%,两组比较差异有显著性(χ~2=15.048,P<0.05)。结论 ALA-PDT联合CO_2激光治疗尖锐湿疣效果确切,值得临床推广应用。Objective To observe the clinical efficacy of 5-aminolevulinic acid（ALA）-photodynamic therapy（PDT）combined with CO2 laserin the treatment of condyloma acuminata（CA）. Methods A total of 219 CA patients were enrolled in this study and randomized to treatment group（n=112）and control group（n=107）.CO_2 laser was used to remove the visible warts in both groups.After removing the warts,the patients in treatment group received 200g/L 5-ALA solution for local wet compress,sealing and avoiding light for 3-4h,and then,XD-635 AB photodynamic therapy（PDT）was carried out-with the power of 260-300 mW,irradiation dose of 100J/cm^2,20 minutes each time,once a week for four weeks.Those in the control group received topical interferon gel,four times a day for four weeks.The efficacy was evaluated after one,two,three and six months of treatment. Results A three-month following up showed that 97 patients in the treatment group were clinically cured,cure rate being86.6%,and in control group,69 were cured,cure rate 64.5%,the difference in cure rate between the two groups was significant（χ~2=14.597,P〈0.05）.A six-month follow-up showed 95（84.8%）in treatment group were cured and 66（61.7%）in control group were cured,the difference between the two groups was significant（χ~2=15.048,P〈0.05）. Conclusion ALA-PDT combined with CO_2 laser is effective and safe in the treatment of condyloma acuminata and worthy of clinical popularization and application.

关 键 词：氨基酮戊酸 光化学疗法 尖锐湿疣 治疗结果 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]