活血益气方联合依达拉奉对急性脑梗死患者同型半胱氨酸、高敏C反应蛋白及D-二聚体水平的影响  

Effect of Huoxue Yiqi formula combined with edaravone on levels of homocysteine, high-sensitivity C-reactive protein, and D-dimer in patients with acute cerebral infarction

作　　者：杨玲[1] 李秋菊[1] 

机构地区：[1]寿光市人民医院神经内三科,262700

出　　处：《国际医药卫生导报》2016年第20期3121-3124,共4页International Medicine and Health Guidance News

摘　　要：目的探讨活血益气方联合依达拉奉对急性脑梗死患者同型半胱氨酸、高敏C反应蛋白及D-二聚体水平的影响。方法将本研究纳入的81例急性脑梗死患者随机分为研究组4l例与对照组40例。对照组静脉滴注依达拉奉治疗，研究组在静脉滴注依达拉奉基础上服用活血益气方治疗。两组疗程均为28d。对比分析两组疗效，治疗前后神经功能缺损（NIHSS）评分、日常生活活动能力（ADL）评分、同型半胱氨酸、高敏C反应蛋白及D-二聚体水平变化以及用药副反应发生情况。结果研究组治疗总有效率（95．12％）高于对照组（72．50％），差异有统计学意义（P〈0．05）；两组治疗后NIHSS评分较治疗前显著下降，ADL评分较治疗前显著上升，差异有统计学意义（P〈0．05）；治疗后，研究组NIHSS评分低于对照组，ADL评分高于对照组，差异有统计学意义（P〈0．05）；两组治疗后血清同型半胱氨酸、高敏C反应蛋白及D-二聚体水平较治疗前均显著下降，差异有统计学意义（P〈0．05）；研究组治疗后同型半胱氨酸、高敏C反应蛋白及D-二聚体水平低于对照组，差异有统计学意义（P〈0．05）；两组患者均未发生明显的药物副反应。结论活血益气方联合依达拉奉可明显降低急性脑梗死患者同型半胱氨酸、高敏C反府蛋白及D-二聚体水平．且治疗效果显著，值得研究。Objective To investigate the effect of Huoxue Yiqi formula combined with edaravone on the levels of homocysteine, high-sensitivity C-reactive protein, and D-dimer in patients with acute cerebral infarction. Methods 81 patients with acute cerebral infarction were randomly divided into a study group（n=41） and a control group（n=40）. The control group were intravenously dripped edaravone; in addition, the study group were treated with Huoxue Yiqi formula. Both groups were treated for 28 d. The clinical efficacy, the neural function defect score （NIHSS）, activities of daily living （ADL） score, the changes of homocysteine, high-sensitive C-reactive protein, and D-dimer levels before and after the treatments, and the incidence of adverse drug reactions were compared between these two groups. Results The total effective rate was significantly higher in the study group than in the control group （95.12% vs. 72.50%）, with a statistical difference （P 〈 0.05）. After treatments, the NIHSS score was significantly lower, the ADL score was obviously higher, and the serum levels of homocysteine, high-sensitive C-reactive protein, and D dimer were markedly lower after than before the treatment in both groups and so in the study group than in the control group after the treatment, with statistical differences（P 〈 0.05）. No obvious adverse drug reactions occurred during the treatment course in both groups. Conclusions Huoxue Yiqi formula combined with edaravone in the treatment of acute cerebral infarction is significantly effective and canapparently decrease the levels of homocysteine, high-sensitive C-reactive protein, and D dimer level, so it is worth being further studied.

关 键 词：活血益气方 依达拉奉 急性脑梗死 同型半胱氨酸 高敏C反应蛋白 D-二聚体 

分 类 号：R714.246[医药卫生—妇产科学]