分泌性中耳炎病人中耳积液及血清相关炎性递质检测  

DETECTION OF MIDDLE EAR EFFUSION AND SERUM RELATED INFLAMMATORY MEDIATORS IN PATIENTS WITH SECRETORY OTITIS MEDIA

作　　者：周长华[1] 桂明才[1] 徐丹[1] 刘波[1] 

机构地区：[1]达州市中心医院耳鼻咽喉头颈外科,四川达州635000

出　　处：《齐鲁医学杂志》2016年第4期454-455,共2页Medical Journal of Qilu

摘　　要：目的探讨分泌性中耳炎病人中耳积液及血清中白细胞介素-1β（IL-1β）、白细胞介素-5（IL-5）、白细胞介素-8（IL-8）及肿瘤坏死因子-α（TNF-α）的变化情况。方法选取分泌性中耳炎病人80例为观察组,同期健康查体人员80例为对照组,检测两组中耳积液及血清炎性递质IL-1β、IL-5、IL-8及TNF-α水平并进行比较。结果观察组血清炎性递质IL-1β、IL-5、IL-8及TNF-α水平均高于对照组,差异有显著性（t=2.97~3.83,P〈0.05）。观察组中不同分类及积液性质病人的血清及中耳积液IL-1β、IL-5、IL-8及TNF-α水平比较,差异均有显著性（F=3.97~10.06,t=2.73~3.93,P〈0.05）。结论对分泌性中耳炎病人中耳积液及血清IL-1β、IL-5、IL-8及TNF-α水平进行检测有重要价值。Objective To investigate the changes of ear effusion and serum inflammatory mediators-IL-1β,IL-5,IL-8 and TNF-α-in patients with secretory otitis media（SOM）. Methods Eighty patients with SOM were selected and served as the observation group,and 80 healthy persons served as the control.Middle ear effusion,serum inflammatory mediators were detected and compared between the two groups. Results The serum levels of inflammatory mediators-IL-1β,IL-5,IL-8 and TNF-α-in the observation group were higher than that in the control group（t=2.97-3.83,P〈0.05）.In the observation group,the levels of IL-1β,IL-5,IL-8 and TNF-αin serum and middle ear effusion-in patients with different classification and effusion-were significant difference（F=3.97-10.06,t=2.73-3.93,P〈0.05）. Conclusion For patients with secretory otitis media,detection of IL-1β,IL-5,IL-8 and TNF-αin middle ear effusion and serum is of great value.

关 键 词：伴渗出液中耳炎 血清 中耳积液 白细胞介素1Β 白细胞介素5 白细胞介素8 肿瘤坏死因子α 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]