儿童腹泻病原菌分布及耐药性分析  

Pathogen distribution and drug resistance analysis of children with diarrhea

作　　者：徐豪[1] 刘慧[1] 刘丽莎[1] 泰淑红[1] 邵艳[1] 

机构地区：[1]郑州大学第三附属医院检验科,河南郑州450052

出　　处：《医学检验与临床》2016年第5期43-44,共2页Medical Laboratory Science and Clinics

基　　金：临床检验诊断学河南省科技厅重点科研团队项目（B20140269）

摘　　要：目的：了解河南地区儿童腹泻主要病原菌分布及其耐药现状，为临床抗菌药物的合理使用提供指导。方法：对2013年1月-2015年12月疑似腹泻患儿大便标本进行细菌培养及药敏实验，分析致病菌分布及耐药情况。结果：2013年-2015年共检出儿童腹泻病原菌58株，其中沙门菌，志贺菌，致病性大肠埃希菌、金黄色葡萄球菌和白色念珠菌分别占28株48.3%；23株39.7%；3株5.2%；2株3.4%，2株3.4%。主要病原菌沙门菌对抗菌药物氨苄西林、环丙沙星和复方磺胺的的耐药率分别为25%、14.3%和10.7%。结论：河南地区儿童腹泻病致病菌以沙门菌、志贺菌和致病性大肠埃希菌为主，抗菌药物环丙沙星和复方磺胺的敏感性较强。Objective： To investigate the distribution and antibiotic resistance of pathogens in children with bacterial diarrhea, and to provide the reference for reasonable use of antibiotics in clinic in Henan area. Methods：Regular bacterial culture of stool sam-ples from children with suspicious bacterial diarrhea was performed to isolate the pathogen during 2013 to 2015, followed by the analysis of its composition and serum and drug resistance to antimicrobacterial drugs. Results： 58 strains of pathogenic bacteria were isolated from diarrhea children during 2013- 2015 , in which salmonella, shigella, enteropathogenic E. coli, Staphylococcus aureus and Candida albicans isolates accounted for 48.3%, 39.7%, 5.2%, 3.4% and 3.4% respectively. Drug resistance rate of the main strains to antimicrobial drugs was 25.0% to ampicillin, 14.3% tociprofloxacin and 10.7% to compound sulfonamides.Conclusion： The pathogenic bacteria causing diarrhea mainly includes salmonella, shigella and enteropathogenic E. coli in children from Henan region, the sensitive antimicrobial reagents for the main strains are ciprofloxacin and compound sulfonamides.

关 键 词：儿童 腹泻 病原菌 耐药性 

分 类 号：R181.34[医药卫生—流行病学]