睡眠呼吸暂停综合征患者睡眠呼吸事件与血氧饱和度下降程度的相关性分析  

Study on the relationship between sleep apnea events and the degree of oxygen desaturation index in the patients with sleep apnea syndrome

作　　者：朱选风 顾建华[1] 刘剑南[1] 陆甘[1] 

机构地区：[1]江苏省老年医院呼吸科,江苏省南京市210024

出　　处：《实用老年医学》2016年第9期756-758,共3页Practical Geriatrics

摘　　要：目的探讨老年睡眠呼吸暂停综合征(SAS)患者睡眠呼吸事件与血氧饱和度(Sp O2)下降程度的相关性。方法回顾性分析76例老年SAS患者夜间多导睡眠监测,统计分析患者所有的睡眠呼吸事件(共13091例次)与Sp O2下降值的关系。睡眠呼吸事件发生前后Sp O2的差值,记为ba,作为因变量,将每次睡眠呼吸事件中的呼吸暂停持续时间和呼吸事件的类型及每例SAS患者的呼吸暂停低通气指数(AHI)、年龄、体质量指数(BMI)作为自变量,做重复测量的广义估计方程。结果 ba=-6.99+0.16持续时间-0.04年龄+0.42 BMI+0.05 AHI(P均<0.05)。ba与呼吸事件中的呼吸暂停持续的时间、呼吸事件的类型、患者的年龄及BMI的回归系数均有统计学意义。其余自变量不变的情况下,呼吸暂停持续时间增加1 s,以阻塞性呼吸暂停为参数,中枢性呼吸暂停引起的ba与其相比差异无统计学意义,混合性呼吸暂停引起的ba是阻塞性呼吸暂停的0.68倍;低通气引起的ba是阻塞性呼吸暂停的0.63倍。结论呼吸事件的类型不同,引起的低氧程度不同,其中中枢性与阻塞性导致的缺氧最严重;混合性呼吸暂停与低通气导致的缺氧较之为轻;同样的呼吸暂停时间,患者AHI越大,年龄越轻,BMI越大,Sp O2下降程度越大。Objective To explore the relationship of sleep events with blood oxygen saturation in the patients with sleep apnea syndrome（ SAS）. Methods The polysomnography data of 76 elderly patients with SAS were analyzed. The difference value of Sp O2 before and after the sleep events was set as ba. The dependent variable ba and independent variables such as sleep apnea duration time,type of sleep event,apnea hyponea index（ AHI）,age and body mass index（ BMI） were inviteded to generalized estimate equation. Results（ 1） ba =-6. 99＋0. 16 time-0. 04 age＋0. 42 BMI＋0. 05 AHI（ all P〈0. 05）.（ 2） Compared with obstructive sleep apnea,there was no significant difference in the decrease of Ba in central sleep apnea. Ba caused by mixed sleep apnea was 0. 68 times of obstructive sleep apnea,while Ba caused by hypopnea was 0. 63 times of obstructive sleep apnea. Conclusions Different types of sleep event could result in various levels of hypoxia. The decrease of Sp O2 caused by central sleep apnea and obstructive sleep apnea is more severe than mixed sleep apnea and hypopnea.During the same sleep apnea duration time,patients with higher AHI and BMI,younger age would have lower Sp O2.

关 键 词：睡眠呼吸暂停 睡眠呼吸事件 血氧饱和度 

分 类 号：R563[医药卫生—呼吸系统]