甲状腺功能亢进症患者左心室峰值应变与血浆B型脑钠肽的相关性研究  

Correlation Analysis on Left Ventricular Peak Strain and Plasma BNP Level in Patients with Hyperthyroidism

作　　者：姜艳娜 黄朴忠 李焱 赵洋 

机构地区：[1]辽宁省金秋医院,辽宁沈阳110016

出　　处：《中国医学创新》2016年第27期28-31,共4页Medical Innovation of China

摘　　要：目的:应用三维斑点追踪成像技术(3D-STI)评价甲状腺功能亢进症(甲亢)患者左心室整体收缩功能,并探讨左心室整体峰值应变与血浆B型脑钠肽(BNP)水平的相关性。方法:选取2015年5-11月本院收治的63例甲亢患者作为研究对象,根据甲亢及甲状腺心脏病诊断标准分为甲亢组31例和甲亢心组32例,另择同期健康志愿者30例作为对照组,三组均行常规和三维超声心动图检查,测量左室舒张末期内径(LVDD)、左室收缩末期内径(LVSD)、室间隔厚度(IVST)、左室后壁舒张末期厚度(LVPWT)、左室射血分数(LVEF)、左室整体峰值纵向应变(GLS)、圆周应变(GCS)、面积应变(GAS)及径向应变(GRS)及血浆BNP水平。结果:GLS、GCS、GAS及GRS值甲亢组均低于对照组(P<0.05),甲亢心组均低于甲亢组及对照组(P<0.05);甲亢组LVDD、LVSD、IVST、LVPWT及LVEF值与对照组比较差异均无统计学意义(P>0.05),甲亢心组LVDD、LVSD高于甲亢组和对照组(P<0.01),LVEF均低于甲亢组和对照组(P<0.01),三组间IVST、LVPWT值比较差异均无统计学意义(P>0.05);血浆BNP甲亢组高于对照组,甲亢心组高于甲亢组和对照组,比较差异均有统计学意义(P<0.05);GLS、GCS、GAS及GRS值与BNP水平均呈负相关,其中与GLS与GAS相关性最好。结论:三维斑点追踪技术可早期评价甲状腺功能亢进症患者心脏功能受损情况,其与血浆BNP水平结合可较敏感地反应心功能的变化及心肌损害程度。Objective： To use three-dimensional speckle tracking imaging （ 3D-STI ） to evaluate the left ventricular systolic function in patients with hyperthyroidism and explore the correlation on the left ventrieular peak strain and the level of type B natriuretic peptide （ BNP ） .Method： From May 2015 to November 2015, 63 cases of hyperthyroidism were selected as the research objects, they were divided into hyperthyroidism group of 31 cases and hyperthyroid heart disease group of 32 cases according to the diagnostic criteria of hyperthyroidism and thyroid heart disease.Another 30 cases of healthy volunteers were selected as the control group.Routine and three dimensional echocardiography were performed in the three groups, left ventricular end diastolic diameter （ LVDD ）, left ventricular end systolic diameter （ LVSD ）, interventricular septal thickness （ IVST ）, left ventricular posterior wall end diastolic thickness （ LVPWT ）, left ventricular ejection fraction （ LVEF ）, global longitudinal strain （ GLS ）, circumferential strain （ GCS ）, area strain （ GAS ）, radial strain （ GRS ） and plasma BNP level were measured.Result： GLS, GCS, GAS and GRS in hyperthyroidism group were lower than those of the control group （ P〈0.05 ）, hyperthyroid heart disease group were lower than those of hyperthyroidism group and the control group （P〈0.05）, there were no significant differences in LVDD, LVSD, IVST, LVPWT and LVEF values in the hyperthyroidism group and the control group （ P〉0.05 ）, LVDD and LVSD in hyperthyroid heart disease group were higher than those of hyperthyroidism group and the control group （ P〈O.01 ）, LVEF in hyperthyroid heart disease group were lower than hyperthyroidism group and the control group （ P〈0.01 ）, there were no significant differences in IVST and LVPWT values among three groups （ P〉O.05 ）, plasma BNP level of hyperthyroidism group was higher than that of the control group, hyperthyroid heart disease group were higher t

关 键 词：三维斑点追踪超声心动图 甲状腺功能亢进 左心室功能 脑钠肽 

分 类 号：R581.1[医药卫生—内分泌]