血浆五聚素3(PTX3)浓度与冠心病相关性研究  

The research of the relevance between pentraxin 3(PTX 3) and coronary heart disease

作　　者：谢国波[1] 熊力[1] 杨明[1] 盛国太[1] 余茂生[1] 曹乾嫱[1] 张繁之[1] 李昱[1] 孙汉俊 

机构地区：[1]江西省人民医院心内一科,江西南昌330006

出　　处：《中国当代医药》2016年第27期46-48,共3页China Modern Medicine

基　　金：江西省卫生计生委科技计划项目(20165017)

摘　　要：目的探讨血浆五聚素3（PTX3）浓度与冠心病发生、发展的相关性。方法选取2013年6月~2014年12月我院60例冠心病（CHD）患者作为CHD组,其中急性心肌梗塞（AMI）组、稳定型心绞痛（SAP）组及不稳定型心绞痛（UAP）各20例,另选择20例健康体检者作为对照组,就四组患者的hs-CRP、PTX3水平及Genisin评分进行比较。同时对CHD近期预后的危险因素进行logistic回归分析。结果 CHD组患者的hs-CRP、PTX3及Genisin评分均明显高于对照组,差异有统计学意义（P〈0.05）,UAP组和AMI组在hs-CRP、PTX3及Genisin评分上与SAP组比较,差异均有统计学意义（P〈0.05）。在hs-CRP及PTX3上,AMI组与UAP组比较,差异无统计学意义（P〉0.05）,两组Genisin评分比较,差异有统计学意义（P〈0.05）。结论高血压、LDL-C、hs-CRP及PTX3是CHD近期预后的影响因素,伴有急性冠脉综合征的患者,其PTX水平明显升高,可作为早期诊断急性冠脉综合征的临床指标,对于CHD患者的预后评估也能发挥积极作用。Objective To explore the relevance between pentraxin 3（PTX3） and the occurrence and development of coronary heart disease.Methods 60 cases of coronary heart disease（CHD） from July 2013 to December 2014 in our hospital were selected as the CHD groups.There were 20 cases in acute myocardial infarction（AMI） group,stable angina pectoris（SAP） group and unstable angina pectoris（UAP） respectively,20 cases of healthy persons were selected as the control group.Compared hs-CRP,PTX3 levels and Genisin scores between the four groups,and carried out the risk factors for the recent prognosis of CHD by logistic regression analysis.Results In hs-CRP,PTX3,and Genisin score,the scores of CHD group were significantly higher than those of control group,and there were significant differences between groups（P〈0.05）.UAP group and AMI group compared with SAP group,the differences between groups were statistically significant（P〈0.05）.In hs-CRP and PTX3,the differences between the AMI group and the UAP group were not statistically significant（P〉0.05）,and the differences were statistically significant between the two groups in the Genisin score（P〈0.05）.LDL-C,hs-CRP and PTX3 made the influence factors of the recent prognosis of CHD.Conclusion The level of PTX in patients with acute coronary syndrome were significantly increased,which can be used as the early diagnosis of acute coronary syndromeclinical indicators,can play a positive role in the assessment of prognosis in CHD patients.

关 键 词：血浆五聚素3 冠心病 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]