^(60)Co-γ辐照条件下左氧氟沙星降解因素分析  

Factors of Degradation of Levofloxacin Under Irradiation of ^(60)Co-γ

作　　者：吴珂[1] 赵冠人[1] 彭明丽[1] 陈明[1] WU Ke ZHAO Guan-ren PENG Ming-li CHEN Ming(Department of Pharmacy,the 309th Hospital of PLA,Beijing 100091, China)

机构地区：[1]解放军309医院药剂科,北京100091

出　　处：《解放军药学学报》2016年第4期318-321,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：解放军309医院课题;No:2014MS-011

摘　　要：目的探索^(60)Co-γ辐照条件下影响左氧氟沙星降解的因素(辐照剂量、初始浓度、N_2/O_2饱和及自由基清除剂等)。方法分别配制不同初始浓度的左氧氟沙星溶液(10、50、100 mg·L^(-1)、100 mg·L^(-1)+N_2饱和、100 mg·L^(-1)+O_2饱和、100 mg·L^(-1)+10%叔丁醇、左氧氟沙星粉末),经不同辐照剂量(0.3、0.6、1、2.5、5、10 k Gy)的^(60)Co-γ辐照后,利用HPLC法测定溶液中剩余左氧氟沙星的含量。结果左氧氟沙星的降解受到初始浓度及辐照剂量的影响,初始浓度越低,辐照剂量越大,降解越彻底。而粉末状态几乎不降解。与N_2或空气饱和相比,O_2饱和显著降低了左氧氟沙星的降解率。添加自由基清除剂叔丁醇后,左氧氟沙星的降解明显受到了抑制。结论^(60)Co-γ辐照处理可以成为有效降解水体中有害物质的新方法。对左氧氟沙星而言,浓度越低,辐照剂量越大,降解越彻底。Objective To explore the factors（ irradiation dose,initial concentration,saturation with N2/ O2 and free radical scavenger） of degradation of levofloxacin under irradiation of60Co-γ. Methods Levofloxacin solutions of different accurate initial concentrations（ 10,50,100 mg·L-1,100 mg·L-1＋ N2,100 mg·L-1＋ O2,100mg·L-1＋ 10% l tertiary butanol and ievofloxacin powder） were irradiated by60Co-γ at different doses（ 0. 3,0. 6,1,2. 5,5,10 k Gy）. Then,the concentrations of the remaining levofloxacin were determined by HPLC. Results The degradation of levofloxacin,affected by the initial concentration and radiation dose,was thorough at a low initial concentration and a high irradiation dose. And the powder state almost had no degradation. The degradation of levofloxacin with O2 saturation was significantly decreased compared with N2 or air saturation. The degradation of levofloxacin was obviously inhibited when tertiary butanol was added as a free radical scavenger. Conclusion Irradiation with60Co-γ can be a effective method to degrade the harmful substances in water. A low concentration and a high irradiation dose can mean a thorough degradation of levofloxacin.

关 键 词：左氧氟沙星 辐照 降解 自由基清除剂 

分 类 号：R917[医药卫生—药物分析学]