胶原基复合型组织工程化皮肤制备中的关键科学技术问题  

Critical science and technology issues in preparation of collagen based tissue-engineered skin

作　　者：刘婷[1,2] 但卫华[1,2] 但年华[1,2] LIU Ting DAN Weihua DAN Nianhua(The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China The Center of Biomedicine Engineering of Sichuan University,Chengdu 610065, China)

机构地区：[1]四川大学皮革化学与工程教育部重点实验室皮肤组织工程研究室,成都610065 [2]四川大学生物医学工程技术研究中心,成都610065

出　　处：《功能材料》2016年第B06期31-37,共7页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(51473001)

摘　　要：胶原基复合型组织工程化皮肤是未来发展的方向和研究热点。本文在介绍组织工程化皮肤的基础上,简要地综述和探讨了胶原改性的原理与方法、胶原基复合支架材料的造孔方法及其与孔结构之间的关系、种子细胞的选择、细胞与支架材料的复合培养、血管化及其影响因素、及其它皮肤附属器官的再生等关键科学技术问题,并阐明了解决这些科学技术问题的思路和方法,为组织工程化皮肤的研发提供了有益的借鉴。Collagen-based tissue-engineered skin has become the direction of future development and a hot re-search area.This article briefly reviews the research progress of tissue-engineered skin.Critical science and tech-nology issues of preparation on collagen-based tissue-engineered skin,such as the method of modifying and pore-creating of collagen,the selection of seed cells and its co-culture with the collagen scaffold,the regenera-tion of blood vessel and cutaneous appendages will be also indicated in this article.Additionally,the article pro-vides ideas and methods for solving the science and technology problems and offers beneficial lessons to the study of tissue-engineered skin.

关 键 词：胶原 组织工程化皮肤 支架 细胞 血管 

分 类 号：Q81[生物学—生物工程]