叶酸靶向聚合物载药微粒的研究进展  

Progress of folate-targeted polymer drug loading particles

作　　者：李姝婷[1] 王卫京[1] 陈淑花[1] 王景昌[1] 李鸣明[1] 詹世平[1] LI Shuting WANG Weijing CHEN Shuhua WANG Jingchang LI Mingming ZHAN Shiping(College of Environment ＆ Chemical Engineering, Dalian University, Dalian 116622, China)

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《功能材料》2016年第B06期78-82,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(21176032)

摘　　要：介绍了叶酸靶向载药微粒的特性及其作用机制,本节就叶酸靶向药物的高分子载体进行了简要综述。重点阐述了叶酸靶向药物微粒的不同聚合物载体以及制备方法。其中针对传统方法中存在的有机溶剂残留、粒径和形貌难控制等缺点,介绍了一种绿色有效的方法—超临界抗溶剂法(SAS),并对该方法制备载药微粒的原理以及应用进行了简要概括。最后对超临界抗溶剂法制备新型叶酸-聚合物靶向载药微粒进行了展望。The characteristics and principle on the folate-targeted drug particles are described briefly in this arti-cle.It is especially discussed that the different polymers as carrier and preparation methods of the folate-targeted drug loading particles.Aim at the questions of the residual organic solvents,particle size and morphology hard to control and so on in traditional methods,a green and efficient method,supercritical anti-solvent method （SAS）is put forward,and the principles and applications of the method are discussed.Finally new folate-poly-mer targeted drug loading microspheres that prepared by the supercritical CO2 anti-solvent method are prospec-ted.

关 键 词：叶酸 聚合物 载药微粒 超临界抗溶剂法 

分 类 号：TQ31[化学工程—高聚物工业] TB34[一般工业技术—材料科学与工程]