推注速度对静脉曲张用泡沫硬化剂稳定性影响的实验研究  

Experimental Study on Influence of Driving Speed on Foam Stability in Sclerotherapy for the Treatment of Varicose Veins

作　　者：白逃萍 蒋文涛[1] 赵武[2] 万浩[2] 樊瑜波[3,4] BAI Taoping JIANG Wentao ZHAO Wu WAN Hao FAN Yubo(Provincial Key Laboratory of Biomechanical Engineering, Sichuan University, Chengdu 610065, China College of Manufacturing Science and Engineering, Sichuan University, Chengdu 610065, China The Key Laboratory for Biological and Biomechanical of the Education Ministry of China, Beijing University of Aeronautics and Astronautics, Beijing 100191, China National Rehabilitation Auxiliary Equipment Research Center, Beijing 100176, China)

机构地区：[1]四川大学工程力学系,生物力学工程省重点实验室,成都610065 [2]四川大学制造科学与工程学院,成都610065 [3]北京航空航天大学生物与医学工程学院生物力学与生物学教育部重点实验室,北京100191 [4]国家康复辅具研究中心,北京100176

出　　处：《生物医学工程学杂志》2016年第5期890-895,共6页Journal of Biomedical Engineering

基　　金：四川省应用基础研究项目资助(2016JY0182)

摘　　要：泡沫硬化疗法是治疗下肢静脉曲张的主要方法之一，了解泡沫稳定性的影响因素有助于减少治疗的副作用，达到最好的治疗效果。实验中选用5 mL注射器，液气比1：4，环境温度为20℃，进行了9组不同推注速度的实验。全程摄像，每组重复实验5次，对稳定性指标（析水时间、半衰期、泡沫半衰期体积量和析水率曲线）进行对比分析。结果显示，推注速度从100-275 mm/s逐渐增大时，泡沫的析水时间和半衰期呈现升高的趋势；高于275 mm/s之后，则呈下降趋势。析水时间最大差异高达340.0%，半衰期最大差异为118.8%。同时，由于压强随推注速度的增加而增大，使得二氧化碳溶解度增大，进而导致泡沫半衰期体积量减少。因此，采用Tessari法制备泡沫硬化剂时，推注速度对泡沫稳定性有显著的影响。随着推注速度增大，泡沫衰变机制由气体扩散为主变为排液为主，使得泡沫稳定性先增高后减小。研究结果显示275 mm/s为最佳推注速度。Foam sclerotherapy is one of the major therapies for varicose veins in lower limbs. It is important to know the influence factor of foam stability which is beneficial to curative effect. The present experiment explored influence of 9 kinds of driving speed on foam stability when using the method of Tessari. Syringes of 5 mL were chosen to do this experiment which was carried out at the liquid gas ratio of 1：4 and the environment temperature of 20℃. A home-made automatic sclerosing foam preparation equipment was used to prepare the foam. A camera recorded the entire process of foam decay. And foam stability indexes which includes drainage time, half-life, foam half-life volume and the drainage rate curve, were analyzed. The results showed that when driving speed ranged from 100 mm/s to 275 mm/s, foam drainage time and the half-life showed a trend of rising. When the driving velocity was greater than 275 mm/s, the foam drainage time and half-life time reduced a little. The largest drainage time and the half-life differences were 340.0% and 118.8% compared to their minimum value. Meanwhile the pressure increased with the increase of driving speed, so that the solubility of carbon dioxide increased and the foam half-life volume decreased with the increase of the driving speed. It can be concluded that when using the method of Tessari to prepare sclerosing foam, driving speed has a significant effect on its stability. With driving speed increasing, foam decay mechanism changes from gas diffusion to liquid drainage as the main function, so the foam stability increased at first and then decreased later. The foam is relatively more stable at the speed of 275 mm/s, which could be considered as the best driving speed.

关 键 词：推注速度 Tessari法 泡沫硬化剂自动制备仪 泡沫硬化剂稳定性 静脉曲张 

分 类 号：R543.6[医药卫生—心血管疾病]