血糖监测用植入式传感器的研究进展  

Research Progress of Implantable Biosensors for Continuous Glucose Monitoring

作　　者：余江渊 李崭虹 陈诚[1] 陈云霞[2] 朱志刚[1] YU Jiangyuan LI Zhanhong CHEN Cheng CHEN YunXia ZHU Zhigang(School of Environmental and Materials Engineering, College of Engineering, Shanghai Polytechnic University, Shanghai 201209, China School of Material and Science and Engineering, Jingdezhen Ceramic Institute, Jingdezhen 333001, China)

机构地区：[1]上海第二工业大学工学部环境与材料工程学院,上海201209 [2]景德镇陶瓷学院材料科学与工程学院,景德镇333001

出　　处：《生物医学工程学杂志》2016年第5期991-997,共7页Journal of Biomedical Engineering

基　　金：上海高校特聘教授(东方学者)计划资助项目;国家自然科学基金资助项目(61471233;21504051);上海市科委基础研究重点资助项目(13NM1401300);上海市教委曙光计划资助项目(14SG52);上海市人才基金资助项目(201346)

摘　　要：连续血糖监测对于重症糖尿病患者至关重要,但目前仍然没有可供临床使用的长效植入式葡萄糖传感器面世。本文介绍了连续血糖监测用传感器分类,重点探讨了传感器植入后的失效机制,指出了提高传感器植入寿命的途径及注意事项,并展望了植入式葡萄糖传感器的未来研究方向。Continuous glucose monitoring plays an important role in severe diabetic patients. However, there is no a- vailable commercial implanted glucose biosensor for long-term clinic application. This paper firstly introduces the classification of biosensors for continuous glucose monitoring, and then discusses the failure mechanism for implanted biosensors. After that, it points out the routes and tips to improve the life time of the biosensor, and finally looks forward to the future development of implanted glucose biosensors.

关 键 词：连续血糖监测 葡萄糖传感器 植入器件 异物反应 

分 类 号：R587.1[医药卫生—内分泌] TP212[医药卫生—内科学]