载脂蛋白Eε4等位基因与急性脊髓损伤预后的相关性  

Apolipoprotein E Epsilon 4 Allele and Outcomes of Traumatic Spinal Cord Injury in a Chinese Han Population

作　　者：乔久涛[1] 刘艾芸 孙崇毅[1] 陈天新[1] 孙崇然[2] 李明[1] 王冬艳[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086 [2]浙江大学医学院附属第二医院,浙江杭州310009

出　　处：《现代生物医学进展》2016年第26期5072-5076,共5页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(H201419);国家自然科学基金项目(80371370)

摘　　要：目的:探讨中国汉族人群中载脂蛋白Eε4等位基因与急性脊髓损伤(ASCI)预后的相关性。方法:采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)方法,检测2012年5月-2015年10月就诊于哈尔滨医科大学附属第二医院脊柱外科的50例(男性患者35例,女性患者15例)颈段(C3-C8)脊髓损伤的中国汉族患者载脂蛋白Eε4等位基因的遗传学状态,并以ASIA脊髓损伤神经学分类标准为患者神经功能恢复情况进行评估,分析中国汉族人群中载脂蛋白Eε4等位基因与急性脊髓损伤预后的相关性。结果:在运动方面,载脂蛋白Eε4阴性的患者恢复情况显著强于载脂蛋白Eε4阳性的患者恢复情况(mean 6.1vs 3.7,P=0.04)。而在针刺觉方面,载脂蛋白Eε4阴性的患者恢复情况显著弱于载脂蛋白Eε4阳性的患者恢复情况(mean 4.0 vs 6.1,P=0.03)。在轻触觉方面,载脂蛋白Eε4阴性和阳性患者的恢复情况没有显著的差异(mean 7.4 vs 5.9,P=0.28)。结论:中国汉族人群中载脂蛋白Eε4等位基因与ASCI的预后密切相关:载脂蛋白Eε4阳性不利于患者运动的恢复,利于患者针刺觉的恢复。Objective： To study the relationship between apolipoprotein Ee4 allele and the outcomes after the acute spinal cord injury （ASCI） in a Chinese Han population. Methods： The genetic status of apolipoprotein E 84 allele was detected for 50 Chinese Han patients with cervical spinal cord injury （C3-C8） treated in Second Affiliated Hospital of Harbin Medical University from May 2012 to October 20 t 5 by restriction fragment length polymorphism polymerase chain reaction （PCR-RFLP） method. Neurological condition was assessed using the American Spinal Injury Association （ASIA） International Standards, and the relationship between apolipoprotein Ee allele and the outcomes after the ASCI in a Chinese Han population was analyzed. Results： Patients with an APOE e4 allele had significantly less motor recovery than did patients without an APOE e4 allele （mean 3.7 vs. 6.1; P = 0.04）, but better sensory-pinprick recovery （mean 6.1vs. 4.0; P = 0.03）. There were no significant differences by APOE e4 allele status in sensory-light touch recovery （mean 7.4vs. 5.9; P = 0.28）. Conclusions： APOE e4 allele is associated with outcomes after ASCI in a Chinese Han population, and An APOE e4 allele is bad for motor recovery and good for sensory-pinprick recovery.

关 键 词：载脂蛋白E 脊髓损伤 基因多态性 

分 类 号：R681[医药卫生—骨科学]