BDNF与T2DM及糖尿病周围神经病变的相关性研究  

Correlation Research of BDNF with T2DM and DPN

作　　者：李大伟[1] 陈金妮[2] 曹晓琳[1] 张全鹏[3] 罗明英[4] 

机构地区：[1]海南医学院附属医院内分泌科,海南海口570102 [2]海南省人民医院内分泌科,海南海口570102 [3]海南医学院解剖学与胚胎学系,海南海口570102 [4]昆明医科大学,云南昆明650500

出　　处：《现代生物医学进展》2016年第26期5184-5186,5195,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81500377)

摘　　要：目的:探讨脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF)与2型糖尿病(Diabetes mellitus type2,T2DM)及糖尿病周围神经病变(Diabetic peripheral neuropathy,DPN)的相关性研究。方法:纳入T2DM及DPN患者各45例,分别对两组患者血压、血糖、血脂、胰岛素抵抗指数(HOMA-IR)、BDNF等指标进行对比分析。对两组患者BDNF表达水平变化的相关因素进行Pearson相关分析以及多因素线性回归分析。结果:DPN组病程、FBG、HOMA-IR、BDNF分别为(12.16±5.84)年、(10.24±3.93)mmol/L、(3.75±2.02)、(3.43±0.94),T2DM组病程、FBG、HOMA-IR、BDNF分别为(7.43±5.29)年、(8.19±3.35)mmol/L、(2.69±1.84)、(4.91±1.67),差异有显著性(P<0.05);多因素线性回归分析显示,病程、感觉阈值与BDNF表达水平相关(P<0.05);Pearson相关分析显示,BDNF表达水平与HOMA-IR存在显著负相关(P<0.05)。结论:DPN患者BDNF水平明显降低,其水平与感觉阈值、病程、HOMA-IR呈现负相关。Objective： To study the correlation of Brain-derived neurotrophic factor （BDNF） with Diabetes mellitus type 2 （T2DM） and Diabetic peripheral neuropathy （DPN）. Methods： 45 T2DM patients and 45 DPN patients were selected. The indexes like blood pressure, blood sugar, blood fat, HOMA-IR and BDNF of two groups were compared. The influence factors for BDNF expression changes of two groups were analyzed through Pearson correlation and multiple linear regression. Results： The disease course, FBG, HOMA-IR, BDNF in DPN group was （12.16± 5.84） years, （10.24± 3.93） mmol/L, （3.75± 2.02） and （3.43± 0.94） respectively, but was （7.43± 5.29） years, （8.19± 3.35） mmol/L, （2.69± 1.84） and （4.91± 1.67）in T2DM group; the differences had statistical significance （P〈0.05）. The multiple linear regression analysis results indicated that the disease course and threshold of feelings was correlated with the expression of BDNF （P〈0.05）. Pearson correlation analysis results indicated that the expression of BDNF was negatively correlated with HOMA-IR （P〈0.05）. Conclusion： For DPN patients, the level of BDNF is greatly reduced and negatively correlated with threshold of feelings, disease course and HOMA-IR.

关 键 词：脑源性神经营养因子 2型糖尿病 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]